Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672759 | 0.80 | DRD2 (0.46) | — | |
| SCHEMBL6672515 | 0.79 | AKT1 (0.40) | — | |
| SCHEMBL6672242 | 0.79 | AKT1 (0.40) | — | |
| SCHEMBL6401322 | 0.75 | OPRL1 (0.49) | — | |
| SCHEMBL6669410 | 0.74 | MC4R (0.42) | — | |
| SCHEMBL6670425 | 0.73 | TP53 (0.42) | — | |
| SCHEMBL6673179 | 0.73 | POLB (0.42) | — | |
| Hydrochloric Acid SCHEMBL6669828 | 0.71 | HTR2A (0.36) | — | |
| SCHEMBL6394968 | 0.70 | NPC1 (0.47) | NOTUMACENPC1RAB9AL3MBTL1 | |
| SCHEMBL6672827 | 0.69 | OPRM1 (0.43) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |