Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672242 | 0.87 | AKT1 (0.40) | — | |
| SCHEMBL6672515 | 0.87 | AKT1 (0.40) | — | |
| SCHEMBL6673179 | 0.84 | POLB (0.42) | ALDH1A1KDM4E | |
| SCHEMBL6670425 | 0.82 | TP53 (0.42) | — | |
| SCHEMBL6674849 | 0.80 | NOTUM (0.38) | — | |
| SCHEMBL6669410 | 0.77 | MC4R (0.42) | DRD2DRD4 | |
| SCHEMBL6673527 | 0.76 | DRD2 (0.42) | DRD2DRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6669828 | 0.73 | HTR2A (0.36) | DRD2 | |
| SCHEMBL6672827 | 0.73 | OPRM1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL6668923 | 0.73 | HTR2A (0.35) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399432-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER INC. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003000677-A1 | SPIROPIPERIDINE COMPOUNDS AS LIGANDS FOR ORL-1 RECEPTOR | PFIZER PHARMACEUTICALS INC. (JP) | 2003-01-03 | — | — | WO | disclosed |