SCHEMBL6670522

SCHEMBL6670522

COc1ccc(NNC=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.52
GAA P10253 4/20 0.52
NPC1 O15118 3/20 0.52
MAPT P10636 3/20 0.52
KDM4E B2RXH2 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
THRB P10828 1/20 0.52
MAPK1 P28482 1/20 0.52
RECQL P46063 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
SMN1; SMN2 Q16637 3/20 0.48
ALDH1A1 P00352 3/20 0.48
CYP2A6 P11509 1/20 0.48
PTGS2 P35354 3/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10794415 0.88 RAB9A (0.71) RAB9ANPC1MAPTKDM4ESMN1; SMN2
SCHEMBL11687936 0.87 CYP1A2 (0.61) RAB9AGAANPC1MAPTKDM4E
SCHEMBL10783773 0.83 MAPT (0.49) RAB9AGAANPC1MAPTKDM4E
SCHEMBL851498 0.79 RAB9A (0.70) RAB9AGAANPC1MAPTKDM4E
SCHEMBL10356279 0.79 ALDH1A3 (0.53) RAB9AGAANPC1MAPTKDM4E
SCHEMBL9785835 0.79 NQO1 (0.52) GAANPC1MAPTKDM4EMAPK1
SCHEMBL10783768 0.78 SMN1; SMN2 (0.43) RAB9AGAANPC1MAPTKDM4E
SCHEMBL225907 0.78 NPC1 (0.56) RAB9AGAANPC1MAPTKDM4E
SCHEMBL11408739 0.77 NPC1 (0.54) RAB9AGAANPC1MAPTKDM4E
SCHEMBL11684135 0.76 CYP1A2 (0.60) GAAMAPTKDM4ENPSR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2120850-A None JP disclosed
JP-61047943-A None JP disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 US disclosed
EP-1057076-B1 HIGH CONTRAST PHOTOGRAPHIC SILVER HALIDE MATERIAL EASTMAN KODAK CO (US) 2004-09-29 EP disclosed
EP-0852024-B1 BLACK-AND-WHITE PHOTOTHERMOGRAPHIC AND THERMOGRAPHIC ELEMENTS COMPRISING HYDROGEN ATOM DONOR COMPOUNDS AS CONTRAST ENHANCERS EASTMAN KODAK CO (US) 2002-11-06 EP disclosed
US-6383711-B1 PHOTOGRAPHIC FILMS WITH SUPPORTS AND SILVER HALIDE EMULSIONS AND HYDROPHILIC COLLOIDS EASTMAN KODAK COMPANY 2002-05-07 US disclosed
EP-0682288-B1 High contrast photographic silver halide material EASTMAN KODAK CO (US) 2001-06-27 EP disclosed
US-5004669-A Printing Plates, Antistatic Agents KONICA CORPORATION (JP) 1991-04-02 US disclosed
EP-0267264-B1 HIGH CONTRAST DEVELOPMENT OF PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-07-25 EP disclosed
EP-0367572-A1 Light-sensitive silver halide photographic material KONICA CORPORATION (JP) 1990-05-09 EP disclosed
JP-H02120850-A SILVER HALIDE PHOTOGRAPHIC SENSITIVE MATERIAL HIGH IN CONTRAST KONICA CORP 1990-05-08 JP disclosed
US-4859568-A Photographic image recording method using silver halide and vinyl monomer FUJI PHOTO FILM CO., LTD. (JP) 1989-08-22 US disclosed
EP-0226184-A2 Nucleation development control agent for photographic silver halide materials and processes EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-06-24 EP disclosed
US-4650746-A HYDRAZIDE NUCLEATING AGENTS EASTMAN KODAK COMPANY (US) 1987-03-17 US disclosed
JP-S6147943-A SILVER HALIDE PHOTOGRAPHIC SENSITIVE MATERIAL KONISHIROKU PHOTO IND CO LTD 1986-03-08 JP disclosed
EP-0032456-B1 METHOD FOR HIGH CONTRAST DEVELOPMENT OF PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-02-02 EP disclosed
EP-0032456-A1 Method for high contrast development of photographic elements EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1981-07-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R RAB9A 3651/4885GAA 3316/4885NPC1 1353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.