Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 3/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | CA7 | P43166 | 2/20 | 0.65 |
| ▸ | CA9 | Q16790 | 2/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909838 | 0.90 | CYP1A2 (0.62) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL3967781 | 0.90 | ACHE (0.71) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL22931133 | 0.88 | NR4A1 (0.76) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL903659 | 0.87 | RAB9A (0.61) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL14104849 | 0.86 | CTSD (0.61) | RAB9AGAAMAPTNPC1MAPK1 | |
| Hydrochloric Acid SCHEMBL6232337 | 0.85 | GAA (0.58) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL8359254 | 0.85 | MAPT (0.58) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL8581249 | 0.85 | GAA (0.58) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL8216660 | 0.84 | LTA4H (0.75) | RAB9AGAAMAPTNPC1MAPK1 | |
| SCHEMBL6889056 | 0.84 | MAPT (0.58) | RAB9AGAAMAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| EP-2243806-B1 | METHOD OF PRODUCING AN AQUEOUS DISPERSION OF SURFACE-TREATED CARBON BLACK | TOKAI CARBON KK (JP) | 2012-03-28 | — | — | EP | disclosed |
| US-20110253008-A1 | AQUEOUS DISPERSION OF SURFACE-TREATED CARBON BLACK AND METHOD OF PRODUCING THE SAME | TOKAI CARBON CO., LTD. | 2011-10-20 | — | — | US | disclosed |
| US-8026370-B2 | Peroxisome proliferator antagonist; hyperlipemia agents; arteriosclerosis; antiischemic agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-27 | — | — | US | disclosed |
| US-20100269732-A1 | AQUEOUS DISPERSION OF SURFACE-TREATED CARBON BLACK AND METHOD OF PRODUCING THE SAME | TOKAI CARBON CO., LTD. (JP) | 2010-10-28 | — | — | US | disclosed |
| EP-2243806-A1 | AQUEOUS DISPERSION OF SURFACE-TREATED CARBON BLACK AND METHOD OF PRODUCING THE SAME | Tokai Carbon Co., Ltd. (JP) | 2010-10-27 | — | — | EP | disclosed |
| US-20080269420-A1 | Shape Memory Epoxy Copolymer | CORNERSTONE RESEARCH GROUP, INC. | 2008-10-30 | — | — | US | disclosed |
| US-5874443-A | BIOSYNTHESIS | TREGA BIOSCIENCES, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0692033-B1 | ENHANCEMENT OF CHEMILUMINESCENT REACTIONS | BRITISH TECH GROUP (GB) | 1998-03-11 | — | — | EP | disclosed |
| US-5512451-A | MIXTURE OF A AROMATIC DIACYL CYCLIC HYDRAZIDE, PEROXIDASE CATALYST AND OXIDIZER | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| WO-1994023060-A2 | ENHANCEMENT OF CHEMILUMINESCENT REACTIONS | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1994-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | RAB9A 2490/4885GAA 2514/4885MAPT 1631/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | RAB9A 2490/4885GAA 2514/4885MAPT 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.