Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.74 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.74 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.74 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.58 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | MGAM | O43451 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | SI | P14410 | 3/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050183 | 0.85 | NR4A1 (1.00) | NR4A1NR4A2NR4A3SLC9A1PDE4B | |
| SCHEMBL29353751 | 0.84 | NR4A1 (0.74) | NR4A1NR4A2NR4A3SLC9A1PDE4B | |
| SCHEMBL28202474 | 0.84 | NR4A1 (0.74) | NR4A1NR4A2NR4A3SLC9A1PDE4B | |
| SCHEMBL13078324 | 0.84 | NR4A1 (0.74) | NR4A1NR4A2NR4A3SLC9A1PDE4B | |
| SCHEMBL4949839 | 0.84 | SLC9A1 (1.00) | NR4A1NR4A2NR4A3SLC9A1 | |
| SCHEMBL28747774 | 0.82 | ALDH1A1 (0.57) | NR4A1NR4A2NR4A3SLC9A1GAA | |
| SCHEMBL4949353 | 0.81 | NR4A1 (0.70) | NR4A1NR4A2NR4A3SLC9A1PDE4B | |
| SCHEMBL27585207 | 0.81 | SLC9A1 (0.72) | SLC9A1PDE4BMGAMGAASI | |
| SCHEMBL5842720 | 0.80 | SLC9A1 (0.74) | SLC9A1GAAKDM4EALDH1A1HPGD | |
| SCHEMBL13044131 | 0.80 | NR4A1 (0.68) | NR4A1NR4A2NR4A3SLC9A1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | claimed |
| EP-1453828-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | AstraZeneca AB (SE) | 2004-09-08 | — | — | EP | claimed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | claimed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |