Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.68 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.60 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.59 |
| ▸ | FEN1 | P39748 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053844 | 0.84 | HDAC8 (0.73) | HDAC8HDAC6AKR1C3NPC1PKM | |
| SCHEMBL31295303 | 0.84 | HDAC8 (0.73) | HDAC8AKR1C3NPC1PKMKAT6A | |
| SCHEMBL2830822 | 0.84 | HDAC8 (0.73) | HDAC8AKR1C3NPC1PKMKAT6A | |
| SCHEMBL7053842 | 0.84 | HDAC8 (0.73) | HDAC8HDAC1HDAC6AKR1C3NPC1 | |
| SCHEMBL13188232 | 0.83 | HDAC8 (0.71) | HDAC8HDAC1HDAC6ERCC5FEN1 | |
| SCHEMBL7152809 | 0.83 | FFAR1 (0.75) | HDAC8HDAC1HDAC6AKR1C3NPC1 | |
| SCHEMBL8248607 | 0.81 | ALDH1A1 (0.72) | HDAC8AKR1C3NPC1PKMKAT6A | |
| SCHEMBL8782975 | 0.81 | HDAC8 (0.69) | HDAC8AKR1C3NPC1PKMKAT6A | |
| M-Phenoxybenzoic Acid For Cis-Isomer SCHEMBL29522837 | 0.81 | AKR1C3 (1.00) | HDAC8AKR1C3NPC1PKMERCC5 | |
| SCHEMBL21887184 | 0.81 | AKR1C3 (0.78) | HDAC8AKR1C3NPC1PKMKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461010-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | Integriderm, Inc. (US) | 2004-09-29 | — | — | EP | claimed |
| US-20030199558-A1 | Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners | INTEGRIDERM, INC. | 2003-10-23 | — | — | US | claimed |
| WO-2003057184-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | INTEGRIDERM, INC. (US) | 2003-07-17 | — | — | WO | claimed |
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-22 | — | — | US | disclosed |
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-22 | — | — | US | disclosed |
| US-9745613-B2 | Compounds, substrates and methods related to histone deacetylases | THE BROAD INSTITUTE, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745613-B2 | Compounds, substrates and methods related to histone deacetylases | THE BROAD INSTITUTE, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
| WO-2013059582-A2 | SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES | NUPOTENTIAL, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| WO-2008101186-A1 | INHIBITORS FOR HDAC8 | THE J. DAVID GLADSTONE INSTITUTES (US) | 2008-08-21 | — | — | WO | disclosed |
| EP-1461010-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | Integriderm, Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003057184-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | INTEGRIDERM, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051314-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | HDAC1, HDAC11, HDAC10 | HDAC8 18/4885HDAC1 1/4885HDAC6 16/4885 |
| US-20030199558-A1 | Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners | TYR, MC1R, MITF | HDAC8 544/4885HDAC1 466/4885HDAC6 647/4885 |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | HDAC1, HDAC11, HDAC10 | HDAC8 20/4885HDAC1 1/4885HDAC6 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.