Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674722 | 0.92 | KMO (0.57) | KMT2AKMOBCL2L1MCL1PPARG | |
| SCHEMBL6671105 | 0.89 | KMO (0.54) | KMT2AKMOBCL2L1MCL1PPARG | |
| SCHEMBL6672055 | 0.89 | KMT2A (0.50) | KMT2AKMOPPARGPPARAMEN1 | |
| SCHEMBL6663030 | 0.87 | ALDH1A1 (0.47) | KMT2AKMOBCL2L1MCL1ALDH1A1 | |
| SCHEMBL6674727 | 0.84 | KMT2A (0.47) | KMT2AKMOBCL2L1MCL1MGAM | |
| SCHEMBL6675156 | 0.84 | NPC1 (0.53) | KMT2AKMOPPARGPPARAGAA | |
| SCHEMBL6670996 | 0.82 | ALDH1A1 (0.51) | KMT2AKMOMEN1ALDH1A1LMNA | |
| SCHEMBL3104154 | 0.82 | KMT2A (0.68) | KMT2AKMOBCL2L1MCL1PPARG | |
| SCHEMBL3110072 | 0.82 | LDHA (0.54) | KMT2AKMOBCL2L1MCL1PPARG | |
| SCHEMBL6672057 | 0.81 | NPC1 (0.46) | KMT2APPARGPPARAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448181-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GmbH (DE) | 2004-08-25 | — | — | EP | claimed |
| WO-2003045368-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2003-06-05 | — | — | WO | claimed |
| EP-1448181-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GmbH (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045368-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A COMBINATION OF METFORMIN AND A 4-OXOBUTANOIC ACID, AND THE USE THEREOF FOR TREATING DIABETES | MERCK PATENT GMBH (DE) | 2003-06-05 | — | — | WO | disclosed |