Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 7/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672295 | 0.69 | AKR1B1 (0.45) | AKR1B1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL6672301 | 0.67 | KCNA3 (0.35) | AKR1B1MAOB | |
| SCHEMBL17179760 | 0.62 | MCL1 (0.61) | AKR1B1PIM1PIM2TBK1MEN1 | |
| SCHEMBL22044994 | 0.62 | EPHX2 (0.47) | AKR1B1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL30608272 | 0.60 | NPC1 (0.55) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2515353 | 0.60 | MAOA (0.60) | TBK1MAOBMEN1KMT2ACYP1A1 | |
| SCHEMBL15714086 | 0.60 | HIF1A (0.58) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25469041 | 0.59 | — | — | |
| SCHEMBL6646351 | 0.58 | AKR1B1 (0.47) | AKR1B1CYP3A4 | |
| SCHEMBL15842829 | 0.58 | MCL1 (0.58) | CSNK2A2CSNK2BMEN1KMT2ACYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |