Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 8/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672298 | 0.69 | AKR1B1 (0.41) | AKR1B1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL17179760 | 0.62 | MCL1 (0.61) | AKR1B1PIM1PIM2MEN1KMT2A | |
| SCHEMBL4452391 | 0.62 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL22044994 | 0.62 | EPHX2 (0.47) | AKR1B1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL23013725 | 0.60 | METAP2 (0.60) | — | |
| SCHEMBL15714086 | 0.60 | HIF1A (0.58) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1725632 | 0.59 | KIF11 (0.47) | NOTUM | |
| SCHEMBL27974737 | 0.59 | — | — | |
| SCHEMBL4593973 | 0.59 | PIM1 (0.65) | AKR1B1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL6646356 | 0.58 | AKR1B1 (0.59) | AKR1B1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |