Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446704 | 0.78 | KIF11 (0.42) | KCNA3MAOBAKR1B1MAPTTP53 | |
| SCHEMBL6672298 | 0.67 | AKR1B1 (0.41) | MAOBAKR1B1 | |
| SCHEMBL17324007 | 0.67 | CA1 (0.40) | KCNA3MAPTTP53SMN1; SMN2NOTUM | |
| SCHEMBL13561307 | 0.65 | PON1 (0.41) | KCNA3MAPTKDM4EALDH1A1 | |
| SCHEMBL21116465 | 0.63 | TP53 (0.46) | MAOBMAPTTP53SMN1; SMN2EPHX2 | |
| SCHEMBL18015849 | 0.61 | MTNR1A (0.45) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL25027174 | 0.61 | ALDH1A1 (0.42) | MAT2AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31053833 | 0.61 | ALDH1A1 (0.42) | MAT2AMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20274083 | 0.61 | EPHX2 (0.41) | MAOBMAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL17107553 | 0.61 | PTPN1 (0.50) | MAOBKDM4EEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |