Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649013 | 0.89 | CYP1A2 (0.52) | KDM4EALDH1A1L3MBTL1ACKR3GAA | |
| SCHEMBL5254353 | 0.87 | ACKR3 (0.72) | ACKR3 | |
| SCHEMBL6673900 | 0.78 | P2RX7 (0.61) | ALDH1A1GAAKMT2ARAB9AGRM4 | |
| SCHEMBL6670691 | 0.77 | P2RX7 (0.55) | KDM4EALDH1A1L3MBTL1ACKR3GAA | |
| SCHEMBL6102659 | 0.76 | HIF1A (0.51) | KDM4EALDH1A1L3MBTL1TNFHIF1A | |
| SCHEMBL694950 | 0.76 | RAB9A (0.73) | KDM4EALDH1A1L3MBTL1TNFGAA | |
| SCHEMBL6649769 | 0.76 | ACKR3 (0.65) | ALDH1A1ACKR3HIF1AEPAS1LMNA | |
| SCHEMBL13726856 | 0.75 | GRM4 (0.66) | KDM4EL3MBTL1GAAKMT2AGRM4 | |
| SCHEMBL15156423 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1L3MBTL1TNFGAA | |
| SCHEMBL9035239 | 0.75 | KDM4E (0.72) | KDM4EALDH1A1L3MBTL1TNFGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035076-A1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2003-05-01 | — | — | WO | disclosed |