Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD5 | P21918 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6674732 | 0.99 | DRD3 (0.45) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL7773593 | 0.93 | DRD3 (0.51) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL7771951 | 0.86 | DRD3 (0.49) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL7772096 | 0.86 | SLC6A3 (0.58) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL6672587 | 0.86 | LMNA (0.46) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL7794410 | 0.86 | LMNA (0.52) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| Hydrochloric Acid SCHEMBL7796038 | 0.86 | DRD3 (0.48) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| Hydrochloric Acid SCHEMBL6676863 | 0.86 | LMNA (0.46) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| Hydrochloric Acid SCHEMBL7794406 | 0.85 | LMNA (0.51) | DRD3HTR2AADRA1AHRH1SLC6A3 | |
| SCHEMBL6673085 | 0.85 | DRD3 (0.54) | DRD3HTR2AADRA1AHRH1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120410-B1 | Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors | BIOVITRUM AB (SE) | 2004-10-06 | — | — | EP | claimed |
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | claimed |
| EP-1120410-B1 | Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors | BIOVITRUM AB (SE) | 2004-10-06 | — | — | EP | disclosed |
| EP-1120410-A1 | Nicotinic acid esters useful as CNS agents and having affinity for 5-HT receptors | Pharmacia AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| US-5658910-A | TREATING MENTAL DISORDERS | PHARMACIA AB (SE) | 1997-08-19 | — | — | US | disclosed |
| EP-0673368-A1 | NOVEL NICOTINIC ACID ESTERS | Pharmacia & Upjohn Aktiebolag (SE) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994000434-A1 | NOVEL NICOTINIC ACID ESTERS | KABI PHARMACIA AB (SE) | 1994-01-06 | — | — | WO | disclosed |