Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647197 | 0.90 | CYP1A2 (0.53) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL6646639 | 0.88 | HRH3 (0.51) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL6671574 | 0.83 | CYP3A4 (0.49) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL6649246 | 0.73 | CYP3A4 (0.54) | CYP1A2CYP3A4HRH3LMNAALDH1A1 | |
| SCHEMBL3994665 | 0.72 | CYP1A2 (1.00) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL3993201 | 0.69 | HRH3 (1.00) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL6672936 | 0.68 | CYP1A2 (0.56) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL18837471 | 0.68 | LTA4H (0.84) | HRH3LTA4H | |
| SCHEMBL13442 | 0.67 | HRH3 (0.71) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 | |
| SCHEMBL10525513 | 0.67 | HRH3 (0.71) | CYP1A2CYP3A4HRH3TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |