Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649246 | 0.90 | CYP3A4 (0.54) | CYP3A4CYP2D6CYP2C19MAPK13MAPK12 | |
| SCHEMBL6672933 | 0.83 | CYP1A2 (0.56) | CYP3A4SIGMAR1L3MBTL1LMNARAB9A | |
| SCHEMBL6646639 | 0.75 | HRH3 (0.51) | CYP3A4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4331523 | 0.74 | TDP1 (0.70) | CYP3A4CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL6647197 | 0.73 | CYP1A2 (0.53) | CYP3A4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6671580 | 0.70 | CYP3A4 (0.56) | CYP3A4CYP2D6CYP2C19KDM4EPOLB | |
| SCHEMBL6634823 | 0.69 | HRH3 (0.66) | CYP3A4CYP2D6CYP2C19DYRK1AKDM4E | |
| Hydrochloric Acid SCHEMBL11142875 | 0.68 | HRH3 (0.63) | CYP3A4CYP2D6CYP2C19DYRK1AKDM4E | |
| SCHEMBL6653067 | 0.68 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP2C19MAPK13MAPK12 | |
| SCHEMBL6653062 | 0.68 | CYP3A4 (0.47) | CYP3A4CYP2D6CYP2C19MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |