Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP4 | P49662 | 1/20 | 0.57 |
| ▸ | CASP5 | P51878 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | LSS | P48449 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10525513 | 1.00 | HRH3 (0.71) | HRH3CYP1A2CYP3A4HRH4L3MBTL1 | |
| SCHEMBL2208141 | 1.00 | HRH3 (0.71) | HRH3CYP1A2CYP3A4HRH4L3MBTL1 | |
| SCHEMBL3994683 | 0.98 | HRH3 (0.67) | HRH3CYP1A2CYP3A4HRH4L3MBTL1 | |
| SCHEMBL28269086 | 0.89 | LSS (0.66) | HRH3CYP3A4L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL30341140 | 0.88 | HRH3 (0.54) | HRH3CYP1A2CYP3A4HRH4L3MBTL1 | |
| SCHEMBL4277270 | 0.84 | HRH3 (1.00) | HRH3HRH4L3MBTL1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL7468055 | 0.81 | HRH3 (0.95) | HRH3HRH4L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4022095 | 0.81 | CXCR4 (0.72) | HRH3CYP3A4TDP1ALDH1A1CYP2D6 | |
| SCHEMBL15473911 | 0.81 | CHKA (0.70) | KDM4ECCR2 | |
| SCHEMBL11201497 | 0.81 | HRH3 (0.94) | HRH3HRH4L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | claimed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | claimed |
| US-20240245670-A1 | DOSING REGIMEN AND PHARMACEUTICAL COMBINATION COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | NOVARTIS AG (CH) | 2024-07-25 | — | — | US | disclosed |
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | disclosed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | disclosed |
| US-20220373541-A1 | Tri-functional Crosslinking Reagents | ETH ZURICH (CH) | 2022-11-24 | — | — | US | disclosed |
| US-11385225-B2 | Tri-functional crosslinking reagents | ETH ZURICH (CH) | 2022-07-12 | — | — | US | disclosed |
| EP-3374348-B1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ETH ZUERICH (CH) | 2021-11-24 | — | — | EP | disclosed |
| US-10550093-B2 | Third generation taxoids and methods of using same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-02-04 | — | — | US | disclosed |
| US-20180328922-A1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ETH ZURICH (CH) | 2018-11-15 | — | — | US | disclosed |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2018-07-12 | — | — | US | disclosed |
| CN-1292789-A | 6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines | AWANDIS PHARMACEUTICAL CORP (US) | 2001-04-25 | — | — | CN | disclosed |
| EP-0049173-B1 | PYRIMIDONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL DERIVATIVES CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-07-03 | — | — | EP | disclosed |
| US-4439609-A | 4-TERT-AMINOALKYL, 2-AMINOALKOXY OR 2-AMINOALKYLENETHIOALKYL SUBSTITUTED, CHEMICAL INTERMEDIATES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-03-27 | — | — | US | disclosed |
| US-4396765-A | ANTIASTHMATICS, BRONCHODILATORS | STERLING DRUG INC. (US) | 1983-08-02 | — | — | US | disclosed |
| US-4385058-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| US-4339576-A | Anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory 1-[(benzoylphenyl)-lower-alkyl]piperidines and analogs thereof | STERLING DRUG INC. (US) | 1982-07-13 | — | — | US | disclosed |
| EP-0052311-A1 | 1-((Benzoylphenyl) - lower-alkyl) piperidines and carbinol analogs and preparation thereof | STERLING DRUG INC. (US) | 1982-05-26 | — | — | EP | disclosed |
| EP-0049173-A2 | Pyrimidone derivatives, processes for their preparation and pharmaceutical derivatives containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-04-07 | — | — | EP | disclosed |
| US-4304911-A | ANTIHISTAMINES, ANTIALLERGENS, ANTICHOLINERGIC AGENTS, ANTIINFLAMMATORY AGENTS, BRONCHODILATOR AGENTS, AND ANALGESICS | STERLING DRUG INC. (US) | 1981-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | HRH3 4374/4885CYP1A2 2997/4885CYP3A4 2883/4885 |
| US-11385225-B2 | Tri-functional crosslinking reagents | ADGRF1, FCGR3B, FCGR2A | HRH3 699/4885CYP1A2 1994/4885CYP3A4 1283/4885 |
| US-20240245670-A1 | DOSING REGIMEN AND PHARMACEUTICAL COMBINATION COMPRISING 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES | IKZF1, IKZF2, IKZF3 | HRH3 4782/4885CYP1A2 2248/4885CYP3A4 1376/4885 |
| US-20180194744-A1 | Third Generation Taxoids and Methods of Using Same | CBR3, TUBB3, CBX3 | HRH3 1273/4885CYP1A2 640/4885CYP3A4 1084/4885 |
| US-20220373541-A1 | Tri-functional Crosslinking Reagents | ADGRF1, SIGLEC7, ADGRE5 | HRH3 1080/4885CYP1A2 1464/4885CYP3A4 1058/4885 |
| US-20180328922-A1 | TRI-FUNCTIONAL CROSSLINKING REAGENTS | ADGRF1, FCGR3B, FCGR2A | HRH3 699/4885CYP1A2 1994/4885CYP3A4 1283/4885 |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | HBZ, ZFX, WIZ | HRH3 4374/4885CYP1A2 2997/4885CYP3A4 2883/4885 |
| US-10550093-B2 | Third generation taxoids and methods of using same | CBR3, TUBB3, CBX3 | HRH3 1273/4885CYP1A2 640/4885CYP3A4 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.