Lotrafiban

Lotrafiban

SCHEMBL29596

CN1Cc2cc(C(=O)N3CCC(C4CCNCC4)CC3)ccc2N[C@@H](CC(=O)O)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 1.00
ITGA2B P08514 14/20 1.00
ITGAV P06756 16/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lotrafiban SCHEMBL6673128 1.00 ITGB3 (1.00) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL6673166 1.00 ITGB3 (1.00) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL919968 0.99 ITGB3 (0.98) ITGB3ITGA2BITGAV
Lotrafiban SCHEMBL4432242 0.98 ITGB3 (0.96) ITGB3ITGA2BITGAV
SCHEMBL7499918 0.92 ITGB3 (0.85) ITGB3ITGA2BITGAV
SCHEMBL8526301 0.90 ITGB3 (0.82) ITGB3ITGA2BITGAV
SCHEMBL8194605 0.90 ITGB3 (0.82) ITGB3ITGA2BITGAV
SCHEMBL6675548 0.88 ITGB3 (0.79) ITGB3ITGA2BITGAV
SCHEMBL6958161 0.88 ITGB3 (0.78) ITGB3ITGA2BITGAV
SCHEMBL6958164 0.88 ITGB3 (0.78) ITGB3ITGA2BITGAV

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1076 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119233997-A Tetrahedral antibodies 生物分子控股有限责任公司 2024-12-31 CN claimed
EP-4463485-A2 TETRAHEDRAL ANTIBODIES Biomolecular Holdings LLC (US) 2024-11-20 EP claimed
EP-4439040-A2 HEPARIN-BASED BLOOD SAMPLER WITHOUT PLATELET ACTIVATION Radiometer Medical ApS (DK) 2024-10-02 EP claimed
CN-118384290-A Hybrid immunoglobulins containing non-peptide linkages 生物分子控股有限责任公司 2024-07-26 CN claimed
WO-2023137387-A2 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-20 WO claimed
WO-2023137373-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-20 WO claimed
US-20230220116-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-13 US claimed
US-20230220115-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-13 US claimed
EP-4178615-A1 TETRAHEDRAL ANTIBODIES Biomolecular Holdings LLC (US) 2023-05-17 EP claimed
US-11225490-B2 Prodrugs of secondary amine compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2022-01-18 US claimed
EP-0964684-A4 CRYSTALLINE PHARMACEUTICAL PRODUCT SMITHKLINE BEECHAM CORP (US) 2002-05-29 EP claimed
US-6335330-B1 7-((4,4*-BIPIPERIDIN-1-YL)CARBONYL)-2,3,4,5-TETRAHYDRO-4--METH YL-3-OXO-1H-1,4-BENZODIAZEPINE-2-ACETIC ACID HYDROCHLORIDE; FIBRINOGEN RECEPTOR ANTAGONITS, ANTICOAGULANTS; PREVENTION OF STROKES, RESTENOSIS SMITHKLINE BEECHAM CORPORATION 2002-01-01 US claimed
US-6117866-A Bicyclic fibrinogen antagonists SMITHKLINE BEECHAM CORPORATION (US) 2000-09-12 US claimed
EP-0964928-A1 ENZYMATIC RESOLUTION OF BENZODIAZEPINE-ACETIC ACID ESTERS WITH A LIPASE SMITHKLINE BEECHAM PLC (GB) 1999-12-22 EP claimed
EP-0964684-A1 CRYSTALLINE PHARMACEUTICAL PRODUCT SMITHKLINE BEECHAM CORPORATION (US) 1999-12-22 EP claimed
WO-1998029561-A1 ENZYMATIC RESOLUTION OF BENZODIAZEPINE-ACETIC ACID ESTERS WITH A LIPASE SMITHKLINE BEECHAM PLC (GB) 1998-07-09 WO claimed
WO-1998009629-A1 CRYSTALLINE PHARMACEUTICAL PRODUCT SMITHKLINE BEECHAM CORPORATION (US) 1998-03-12 WO claimed
EP-0738150-A4 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1997-03-19 EP claimed
EP-0738150-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-10-23 EP claimed
WO-1995018619-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1995-07-13 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230220115-A1 TETRAHEDRAL ANTIBODIES FCGR3B, FCGR2A, FCGR1A ITGB3 672/4885ITGA2B 796/4885ITGAV 934/4885
US-20230220116-A1 TETRAHEDRAL ANTIBODIES FCGR3B, FCGR2A, FCGR1A ITGB3 672/4885ITGA2B 796/4885ITGAV 934/4885
US-11225490-B2 Prodrugs of secondary amine compounds HNMT, MAOB, UGT1A1 ITGB3 1314/4885ITGA2B 1164/4885ITGAV 2314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.