Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 6/20 | 0.83 |
| ▸ | RARB | P10826 | 14/20 | 0.48 |
| ▸ | RARG | P13631 | 14/20 | 0.48 |
| ▸ | RARA | P10276 | 12/20 | 0.48 |
| ▸ | RXRA | P19793 | 6/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6662336 | 0.91 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL6662339 | 0.91 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796504 | 0.91 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796502 | 0.91 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796499 | 0.91 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796642 | 0.81 | PLA2G4A (0.66) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796638 | 0.81 | PLA2G4A (0.66) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL9254004 | 0.81 | PLA2G4A (0.69) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8795410 | 0.81 | PLA2G4A (0.69) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8795228 | 0.81 | PLA2G4A (0.69) | PLA2G4ARARBRARGRARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857488-B1 | Compositions for enhancing skin permeation of drugs using permeation enhancers | BRISTOL MYERS SQUIBB CO (US) | 2004-07-21 | — | — | EP | claimed |