Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 5/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 9/20 | 0.44 |
| ▸ | RARG | P13631 | 9/20 | 0.44 |
| ▸ | RARA | P10276 | 8/20 | 0.44 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796638 | 1.00 | PLA2G4A (0.66) | PLA2G4APTGS2AKR1C3AKR1C2RARB | |
| SCHEMBL8795964 | 0.90 | PTGS2 (0.57) | PLA2G4APTGS2AKR1C3AKR1C2RARB | |
| SCHEMBL8795957 | 0.90 | PTGS2 (0.57) | PLA2G4APTGS2AKR1C3AKR1C2RARB | |
| SCHEMBL8795959 | 0.84 | PLA2G4A (0.60) | PLA2G4APTGS2AKR1C3AKR1C2RARB | |
| SCHEMBL8795946 | 0.84 | PLA2G4A (0.60) | PLA2G4APTGS2AKR1C3AKR1C2RARB | |
| SCHEMBL8796153 | 0.81 | PLA2G4A (0.51) | PLA2G4APTGS2RARBRARGRARA | |
| SCHEMBL8796157 | 0.81 | PLA2G4A (0.51) | PLA2G4APTGS2RARBRARGRARA | |
| Bicarbonate SCHEMBL6673968 | 0.81 | PLA2G4A (0.83) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796502 | 0.80 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA | |
| SCHEMBL8796499 | 0.80 | PLA2G4A (1.00) | PLA2G4ARARBRARGRARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629604-B1 | Alicyclic phospholipase A2 inhibitors | BRISTOL MYERS SQUIBB CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5436369-A | Alicyclic phospholipase A2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0629604-A2 | Alicyclic phospholipase A2 inhibitors | Bristol-Myers Company (US) | 1994-12-21 | — | — | EP | disclosed |