Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 5/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20079436 | 0.79 | POLB (0.50) | POLBALDH1A1L3MBTL1PGR | |
| SCHEMBL2987031 | 0.77 | PARP15 (0.41) | PARP15TNKS2PARP10PARP2TNKS | |
| SCHEMBL6670689 | 0.76 | ALDH1A1 (0.40) | PARP15TNKS2PARP10PARP2ALDH1A1 | |
| SCHEMBL2204604 | 0.70 | ELANE (0.40) | PARP15TNKS2PARP10PARP2POLB | |
| SCHEMBL6636939 | 0.70 | HTR4 (0.39) | ALDH1A1ERCC1ERCC5FEN1ERCC4 | |
| SCHEMBL6449573 | 0.70 | PARP15 (0.40) | PARP15TNKS2PARP10PARP2TNKS | |
| SCHEMBL24519200 | 0.69 | POLB (0.50) | PARP15TNKS2PARP10PARP2TNKS | |
| SCHEMBL14227440 | 0.69 | POLB (0.64) | PARP15TNKS2TNKSPARP1POLB | |
| SCHEMBL29458522 | 0.69 | POLB (0.64) | PARP15TNKS2TNKSPARP1POLB | |
| SCHEMBL8141804 | 0.69 | PARP1 (0.40) | PARP15TNKS2PARP10PARP2TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414825-A1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003011868-A1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | claimed |
| EP-1414825-A1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011868-A1 | THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE | ASTRAZENECA AB (SE) | 2003-02-13 | — | — | WO | disclosed |