Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.75 |
| ▸ | PPARA | Q07869 | 11/20 | 0.72 |
| ▸ | PPARD | Q03181 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674254 | 1.00 | PPARG (0.75) | PPARGPPARAPPARD | |
| SCHEMBL6280384 | 0.97 | PPARG (0.77) | PPARGPPARAPPARD | |
| SCHEMBL6280390 | 0.97 | PPARG (0.77) | PPARGPPARAPPARD | |
| Hydrochloric Acid SCHEMBL6279938 | 0.96 | PPARG (0.76) | PPARGPPARAPPARD | |
| Hydrochloric Acid SCHEMBL6279932 | 0.96 | PPARG (0.76) | PPARGPPARAPPARD | |
| SCHEMBL6281356 | 0.94 | PPARG (0.73) | PPARGPPARAPPARD | |
| SCHEMBL6283920 | 0.94 | PPARG (0.73) | PPARGPPARAPPARD | |
| SCHEMBL6283453 | 0.93 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL6282962 | 0.92 | PPARG (0.81) | PPARGPPARAPPARD | |
| SCHEMBL6282965 | 0.92 | PPARG (0.81) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1466909-A1 | HALOGENOBENZYL AMINOPROPIONIC ACID DERIVATIVES | Toaeiyo Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |