Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676029 | 0.88 | TDP1 (0.46) | TDP1TSHRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2061458 | 0.88 | ALDH1A1 (0.49) | ALDH1A1HTTBCHEACHE | |
| SCHEMBL27274797 | 0.87 | GPR35 (0.45) | ALDH1A1HTTNR1D1BCHEACHE | |
| SCHEMBL30658955 | 0.87 | GPR35 (0.45) | ALDH1A1HTTNR1D1BCHEACHE | |
| SCHEMBL24492402 | 0.86 | RIPK1 (0.44) | ALDH1A1HTTNR1D1BCHEACHE | |
| SCHEMBL29465818 | 0.86 | RIPK1 (0.44) | ALDH1A1HTTNR1D1BCHEACHE | |
| SCHEMBL4613668 | 0.80 | ALDH1A1 (0.38) | ALDH1A1HTTNR1D1BCHEACHE | |
| SCHEMBL7647352 | 0.79 | ALDH1A1 (0.48) | TSHRALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL30408067 | 0.79 | ALDH1A1 (0.48) | TSHRALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL30696948 | 0.79 | RIPK1 (0.41) | ALDH1A1HTTNR1D1BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| CN-1075808-C | Aniline derivatives having nitric oxide synthase inhibitory activity | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2001-12-05 | — | — | CN | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |