SCHEMBL6674754

SCHEMBL6674754

CCCCN(CCC)CCc1ccc(O)c(O)c1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 3/20 0.87
DRD3 P35462 3/20 0.87
ADRA1D P25100 3/20 0.87
ADRA1A P35348 3/20 0.87
ADRA1B P35368 3/20 0.87
DRD1 P21728 2/20 0.87
DRD4 P21917 2/20 0.87
DRD5 P21918 2/20 0.87
CYP3A4 P08684 1/20 0.87
CYP2D6 P10635 1/20 0.87
TSHR P16473 1/20 0.87
NFKB1 P19838 1/20 0.87
HIF1A Q16665 1/20 0.87
HSD17B10 Q99714 1/20 0.87
KDM4E B2RXH2 1/20 0.84
PMP22 Q01453 1/20 0.84
OPRM1 P35372 1/20 0.56
OPRD1 P41143 1/20 0.56
OPRK1 P41145 1/20 0.56
IAPP P10997 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL10744684 0.98 KDM4E (0.88) DRD2DRD3ADRA1DADRA1AADRA1B
SCHEMBL29368857 0.93 DRD2 (1.00) DRD2DRD3ADRA1DADRA1AADRA1B
SCHEMBL467093 0.93 DRD2 (1.00) DRD2DRD3ADRA1DADRA1AADRA1B
Bromide SCHEMBL1321255 0.92 KDM4E (1.00) DRD2DRD3ADRA1DADRA1AADRA1B
Hydrochloric Acid SCHEMBL4305739 0.92 DRD2 (0.96) DRD2DRD3ADRA1DADRA1AADRA1B
SCHEMBL10428293 0.86 DRD2 (0.84) DRD2DRD3ADRA1DADRA1AADRA1B
Dopamine SCHEMBL14919131 0.86 DRD2 (0.84) DRD2DRD3ADRA1DADRA1AADRA1B
SCHEMBL7271058 0.85 ADRA1D (0.72) DRD2DRD3ADRA1DADRA1AADRA1B
Hydrochloric Acid SCHEMBL11514533 0.84 DRD2 (0.82) DRD2DRD3ADRA1DADRA1AADRA1B
Bromide SCHEMBL7272108 0.84 KDM4E (0.73) DRD2DRD3ADRA1DADRA1AADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004041207-A2 GHB TREATMENT METHODS BAYLOR RESEARCH INSTITUTE (US) 2004-05-21 WO claimed
WO-2000054773-A1 DOPAMINE AGONISTS IN COMBINATION WITH NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-09-21 WO claimed
WO-2004041207-A2 GHB TREATMENT METHODS BAYLOR RESEARCH INSTITUTE (US) 2004-05-21 WO disclosed
WO-2004039321-A2 COMBINATIVE NICOTINIC/D1 AGONISM THERAPY FOR THE TREATMENT OF ALZHEIMER’S DISEASE MIICRO, INC. (US) 2004-05-13 WO disclosed
WO-2000054773-A1 DOPAMINE AGONISTS IN COMBINATION WITH NITRIC OXIDE DONORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-09-21 WO disclosed
US-4673671-A CONVERSION TO MONO O-PHOSPHATE ESTER SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) 1987-06-16 US disclosed
US-4608391-A NERUOUS SYSTEM DISORDERS, PARKINSON$S DISEASE CORNELL RESEARCH FOUNDATION INC. (US) 1986-08-26 US disclosed
EP-0167204-A1 Method for improving the absorption and effectiveness of a catecholamine compound SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) 1986-01-08 EP disclosed
EP-0161305-A1 PHARMACOLOGICAL APPLICATIONS OF DIPHENYLHALONIUM ION KENNEDY, Thomas P. (US) 1985-11-21 EP disclosed
WO-1985002174-A1 PHARMACOLOGICAL APPLICATIONS OF DIPHENYLHALONIUM ION KENNEDY THOMAS P 1985-05-23 WO disclosed
US-4181738-A DOPAMINERGIC CORNELL RESEARCH FOUNDATION, INC. (US) 1980-01-01 US disclosed