SCHEMBL6674797

SCHEMBL6674797

CC(C)c1nc2c(O)ncn(Cc3cccc(Cl)c3)c-2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 3/20 0.43
ACP1 P24666 1/20 0.42
HTT P42858 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
GLA P06280 1/20 0.42
UBE2N P61088 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
BRD4 O60885 1/20 0.41
HTR6 P50406 4/20 0.41
EGLN1 Q9GZT9 1/20 0.40
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
HTR1A P08908 1/20 0.39
DRD2 P14416 1/20 0.39
HTR2A P28223 1/20 0.39
HTR7 P34969 1/20 0.39
FSCN1 Q16658 1/20 0.39
KDM4E B2RXH2 2/20 0.38
CNR2 P34972 2/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6674155 0.87 KCNH2 (0.42) ACP1HTTSMN1; SMN2BRD4HTR6
SCHEMBL7378986 0.83 YTHDC1 (0.45) YTHDC1ACP1HTTSMN1; SMN2GLA
SCHEMBL6675788 0.79 HSP90AA1 (0.43) SMN1; SMN2L3MBTL1BRD4ADORA2AKDM4E
SCHEMBL6674149 0.79 QPCT (0.40) SMN1; SMN2KDM4ELMNAMAPK1
SCHEMBL6675454 0.78 ALOX15 (0.43) KDM4ELMNATDP1
SCHEMBL6673823 0.77 KDM4E (0.44) HTTSMN1; SMN2L3MBTL1ADORA2AADORA1
SCHEMBL6675823 0.77 MAPK1 (0.46) HTTSMN1; SMN2KDM4ELMNAALDH1A1
SCHEMBL6155699 0.72 KCNH2 (0.42) ACP1HTTSMN1; SMN2BRD4HTR6
SCHEMBL6155742 0.71 PDE4A (0.53)
SCHEMBL7383247 0.70 CTSL (0.32) YTHDC1HTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202628-B1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO CELTIQUE SA (LU) 2004-10-13 EP claimed
EP-1202628-A4 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO CELTIQUE SA (LU) 2002-10-30 EP claimed
EP-1202628-A1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS Euro-Celtique S.A. (LU) 2002-05-08 EP claimed
WO-2001011967-A1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO-CELTIQUE S.A. (LU) 2001-02-22 WO claimed
EP-1202628-B1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO CELTIQUE SA (LU) 2004-10-13 EP disclosed
EP-1202628-A4 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO CELTIQUE SA (LU) 2002-10-30 EP disclosed
EP-1202628-A1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS Euro-Celtique S.A. (LU) 2002-05-08 EP disclosed
WO-2001011967-A1 NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS EURO-CELTIQUE S.A. (LU) 2001-02-22 WO disclosed