Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673331 | 0.96 | MAPK1 (0.45) | ALDH1A1KDM4EMAPK1LMNATSHR | |
| SCHEMBL6672879 | 0.92 | ALDH1A1 (0.37) | ALDH1A1KDM4ELMNAHTTPDE4B | |
| SCHEMBL6674748 | 0.92 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6677675 | 0.80 | MAPT (0.37) | ALDH1A1MAPK1LMNATSHRHTT | |
| SCHEMBL6675820 | 0.79 | MAPK1 (0.46) | ALDH1A1KDM4EMAPK1LMNATSHR | |
| SCHEMBL6677649 | 0.77 | SIGMAR1 (0.43) | ALDH1A1KDM4EMAPK1LMNAPDE4A | |
| SCHEMBL6672378 | 0.76 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6674809 | 0.73 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6674993 | 0.72 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPK1LMNATSHR | |
| SCHEMBL6673336 | 0.70 | PDE4A (0.47) | ALDH1A1KDM4EMAPK1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202628-B1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2004-10-13 | — | — | EP | disclosed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |