Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8164140 | 0.89 | KMT2A (0.44) | MEN1KMT2AHSD17B10RORCLMNA | |
| SCHEMBL6677398 | 0.88 | ITGA4 (0.43) | RORCLMNAALDH1A1ITGA4ITGB7 | |
| SCHEMBL6681036 | 0.88 | ALDH1A1 (0.45) | MEN1KMT2ALMNAALDH1A1ITGA4 | |
| SCHEMBL6676629 | 0.87 | ALDH1A1 (0.45) | MEN1KMT2ALMNAALDH1A1ITGA4 | |
| SCHEMBL6681796 | 0.86 | ALDH1A1 (0.49) | LMNAALDH1A1ITGA4ITGB7SMN1; SMN2 | |
| SCHEMBL6676222 | 0.85 | MAPT (0.48) | MEN1KMT2ALMNAALDH1A1ITGA4 | |
| SCHEMBL1947561 | 0.84 | LMNA (0.42) | MEN1KMT2ALMNAALDH1A1ITGA4 | |
| SCHEMBL30182750 | 0.84 | ALDH1A1 (0.42) | LMNAALDH1A1ITGA4ITGB7SMN1; SMN2 | |
| SCHEMBL4525031 | 0.83 | ALDH1A1 (0.46) | MEN1KMT2ARORCLMNAKDM4E | |
| SCHEMBL4363507 | 0.83 | KMT2A (0.40) | MEN1KMT2AHSD17B10RORCLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |