Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM2 | P31350 | 4/20 | 0.73 |
| ▸ | RRM1 | P23921 | 1/20 | 0.73 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.73 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.73 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.68 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MPI | P34949 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CTH | P32929 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676547 | 1.00 | RRM2 (0.73) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL31238438 | 0.84 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29365763 | 0.84 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29371 | 0.84 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29370 | 0.84 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29362841 | 0.84 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL9267384 | 0.84 | RRM2 (0.52) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL9289701 | 0.84 | RRM2 (0.52) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL1904117 | 0.77 | RRM2 (0.70) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL8684404 | 0.76 | RRM2 (0.57) | RRM2RRM1RRM2BCISD1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089208-A2 | SULFONAMIDE, SULFAMATE AND SULFAMIDE DERIVATIVES OF ANTI-CANCER AGENTS | STICHTING MAASTRICHT RADIATION ONCOLOGY "MAASTRO-CLINIC" (NL) | 2016-06-09 | — | — | WO | claimed |
| WO-2016089208-A2 | SULFONAMIDE, SULFAMATE AND SULFAMIDE DERIVATIVES OF ANTI-CANCER AGENTS | STICHTING MAASTRICHT RADIATION ONCOLOGY "MAASTRO-CLINIC" (NL) | 2016-06-09 | — | — | WO | disclosed |
| WO-2004037159-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FAT METABOLISM | OBETHERAPY BIOTECHNOLOGY (FR) | 2004-05-06 | — | — | WO | disclosed |
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0570294-B1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | UNIV YALE (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5281715-A | 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | disclosed |