Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM2 | P31350 | 5/20 | 0.57 |
| ▸ | RRM1 | P23921 | 1/20 | 0.57 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.57 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.57 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CTH | P32929 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29569419 | 0.85 | RRM2 (0.61) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL1882892 | 0.85 | RRM2 (0.61) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL1882894 | 0.85 | RRM2 (0.61) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL8683080 | 0.79 | RRM2 (0.50) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL6676551 | 0.76 | RRM2 (0.73) | RRM2RRM1RRM2BCISD1NCOA3 | |
| SCHEMBL6676547 | 0.76 | RRM2 (0.73) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29371 | 0.73 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29365763 | 0.73 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29362841 | 0.73 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 | |
| Triapine SCHEMBL29370 | 0.73 | RRM2 (1.00) | RRM2RRM1RRM2BCISD1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | claimed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | claimed |
| US-5721259-A | Method of using 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0570294-B1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | UNIV YALE (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5281715-A | 2-formylpyridine thiosemicarbazone compounds | YALE UNIVERSITY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0570294-A1 | 2-Formylpyridine thiosemicarbazone derivatives, their preparation and their use as antitumor agents | YALE UNIVERSITY (US) | 1993-11-18 | — | — | EP | disclosed |