Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18681421 | 0.77 | NOTUM (0.55) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL2625781 | 0.77 | NOTUM (0.55) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL22240446 | 0.77 | NOTUM (0.55) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL13372442 | 0.77 | NOTUM (0.55) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL30509271 | 0.75 | NOTUM (0.41) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL3702120 | 0.75 | MTNR1A (0.38) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL27903243 | 0.75 | NOTUM (0.41) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL21957933 | 0.75 | HTR2A (0.39) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL19696044 | 0.73 | GPR3 (0.40) | PAX8MTNR1AMTNR1BGPR3NOTUM | |
| SCHEMBL29196012 | 0.73 | HTR2A (0.45) | PAX8MTNR1AMTNR1BGPR3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037865-A4 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | SCRIPPS RESEARCH INST (US) | 2004-03-31 | — | — | EP | disclosed |
| US-20020082424-A1 | Synthesis of CC-1065/duocarmycin analogs | THE SCRIPPS RESEARCH INSTITUTE | 2002-06-27 | — | — | US | disclosed |
| US-6310209-B1 | INTERMEDIATES INVOLVED IN THE 5-EXO-TRIG RADICAL CYCLIZATION OF AN ARYL HALIDE ONTO A TETHERED VINYL CHLORIDE FORMING THE DIHYDROINDOLE C-RING WITH CHLORINE INSTALLED AS A SUITABLE LEAVING GROUP FOR SUBSEQUENT CYCLOPROPANE SPIROCYCLIZATION. | THE SCRIPPS RESEARCH INSTITUTE | 2001-10-30 | — | — | US | disclosed |
| EP-1037865-A1 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | The Scripps Research Institute (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029642-A1 | SYNTHESIS OF CC-1065/DUOCARMYCIN ANALOGS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082424-A1 | Synthesis of CC-1065/duocarmycin analogs | CBR3, C2CD5, SIRT5 | PAX8 4461/4885MTNR1A 2118/4885MTNR1B 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.