Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2034683 | 0.90 | RAB9A (0.52) | RAB9AALDH1A1LMNAAGTR1HTT | |
| SCHEMBL7073273 | 0.84 | KMT2A (0.51) | RAB9AALDH1A1PKMHTTKMT2A | |
| SCHEMBL10924990 | 0.83 | HPGD (0.50) | ALDH1A1LMNAPKMAGTR1HTT | |
| SCHEMBL4854039 | 0.82 | NR1H3 (0.62) | ALDH1A1LMNAHTTKMT2ARXFP1 | |
| SCHEMBL12635556 | 0.81 | ALDH1A1 (0.54) | ALDH1A1LMNAPKMHTTKMT2A | |
| SCHEMBL3803546 | 0.80 | HTT (0.53) | ALDH1A1HTT | |
| SCHEMBL6679384 | 0.80 | CA12 (0.51) | ALDH1A1PKMHTTKMT2AMEN1 | |
| SCHEMBL1835526 | 0.80 | HTT (0.50) | RAB9AALDH1A1LMNAPKMAGTR1 | |
| SCHEMBL101837 | 0.79 | HDAC4 (0.52) | RAB9AALDH1A1PKMHTTKMT2A | |
| SCHEMBL7945209 | 0.79 | CASP3 (0.55) | LMNAHTTKMT2ARXFP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |