Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 9/20 | 0.45 |
| ▸ | MTTP | P55157 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8529712 | 0.99 | APOB (0.44) | APOBMTTPPOLBHSD17B10DRD2 | |
| SCHEMBL691418 | 0.86 | MTTP (0.59) | APOBMTTPKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3887925 | 0.85 | MTTP (0.59) | APOBMTTPKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL8408661 | 0.85 | MTTP (0.59) | APOBMTTPKDM4EMAPT | |
| SCHEMBL6974835 | 0.85 | ABCB1 (0.48) | APOBMTTPDRD2DRD3MEN1 | |
| Hydrochloric Acid SCHEMBL8410108 | 0.85 | MTTP (0.58) | APOBMTTPKDM4EMAPT | |
| SCHEMBL6964486 | 0.85 | PLAU (0.46) | APOBMTTPKMT2AMAPTPRMT5 | |
| SCHEMBL6973499 | 0.84 | SMO (0.45) | APOBMTTPACACB | |
| SCHEMBL6676927 | 0.83 | POLB (0.43) | POLBHSD17B10DRD2DRD3MEN1 | |
| SCHEMBL6974444 | 0.82 | KDM4E (0.44) | APOBMTTPPOLBHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |