Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.48 |
| ▸ | APOB | P04114 | 4/20 | 0.47 |
| ▸ | MTTP | P55157 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.45 |
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973828 | 0.94 | UBE2M (0.45) | ABCB1APOBMTTPHIF1AEPAS1 | |
| SCHEMBL6974687 | 0.90 | ABCB1 (0.41) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6973499 | 0.90 | SMO (0.45) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6967730 | 0.89 | ABCB1 (0.44) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6974444 | 0.89 | KDM4E (0.44) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6968947 | 0.88 | ABCB1 (0.40) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6974667 | 0.88 | MEN1 (0.49) | ABCB1APOBMTTPMEN1KMT2A | |
| SCHEMBL6965865 | 0.88 | APOB (0.41) | ABCB1APOBMTTPNOD1TNF | |
| SCHEMBL6964489 | 0.88 | SMO (0.50) | APOBMTTPHTR2CHTR2B | |
| SCHEMBL6964486 | 0.87 | PLAU (0.46) | APOBMTTPKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |