SCHEMBL6678747

SCHEMBL6678747

O=Cc1cccc2c1COCO2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.38
LMNA P02545 2/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
THRB P10828 1/20 0.38
BLM P54132 1/20 0.38
ABCG2 Q9UNQ0 1/20 0.37
KCNJ1 P48048 1/20 0.37
GSK3B P49841 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HSD17B10 Q99714 1/20 0.35
HPGD P15428 1/20 0.35
ERN1 O75460 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TSHR P16473 2/20 0.33
PKM P14618 1/20 0.33
KDM4E B2RXH2 1/20 0.33
TRIM24 O15164 1/20 0.32
TRIM33 Q9UPN9 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29151144 0.98 TDP1 (0.37) TDP1LMNAKMT2AMEN1THRB
SCHEMBL23668349 0.81 ABCG2 (0.37) ABCG2ALDH1A1
SCHEMBL25274324 0.79 MEN1 (0.39) TDP1LMNAKMT2AMEN1THRB
SCHEMBL31634327 0.78
SCHEMBL31634340 0.78
SCHEMBL4049374 0.75 LMNA (0.33) TDP1LMNAALDH1A1HSD17B10HPGD
SCHEMBL19500892 0.74 GABRA1 (0.38) ABCG2TSHRPKMMAOB
Ammonia Solution, Strong SCHEMBL3820514 0.74 LMNA (0.33) LMNAHPGD
SCHEMBL12043582 0.73 MAP3K14 (0.41) LMNAABCG2ALDH1A1TSHRPKM
SCHEMBL6928146 0.73 ABCG2 (0.39) LMNAABCG2TSHRPKMMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115340497-B Diaryl pyrimidine amide compound or pharmaceutically acceptable salt thereof, pharmaceutical composition and application thereof 安徽医科大学 2023-12-05 CN disclosed
CN-115340497-A Diaryl pyrimidine amide compound or pharmaceutically acceptable salt thereof, pharmaceutical composition and application thereof 安徽医科大学 2022-11-15 CN disclosed
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
US-5856529-A ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-05 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed