Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887021 | 0.81 | MAPT (0.67) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6678263 | 0.81 | PTGIR (0.49) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6679073 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7245284 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1ACHE | |
| SCHEMBL1884692 | 0.76 | KMT2A (0.53) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6678262 | 0.76 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1ACHESMN1; SMN2 | |
| SCHEMBL12235984 | 0.75 | MAPT (0.51) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL31150253 | 0.75 | KMT2A (0.51) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7245278 | 0.75 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1ACHESMN1; SMN2 | |
| SCHEMBL8680075 | 0.73 | KMT2A (0.53) | ALDH1A1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |