Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7247258 | 0.81 | ALDH1A1 (0.56) | ALDH1A1GAAIMPDH2IMPDH1CYP1A2 | |
| SCHEMBL6679031 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL7246130 | 0.79 | MEN1 (0.42) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL7238099 | 0.79 | GLS (0.46) | ALDH1A1GAACYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL6679066 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAKMT2A | |
| SCHEMBL6682248 | 0.78 | ALDH1A1 (0.40) | ALDH1A1GAACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL6681938 | 0.78 | HTT (0.39) | ALDH1A1GAAIMPDH2IMPDH1CYP1A2 | |
| SCHEMBL6678474 | 0.78 | ALDH1A1 (0.39) | ALDH1A1GAACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL6675695 | 0.78 | ALDH1A1 (0.39) | ALDH1A1GAACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL6681804 | 0.77 | GRM2 (0.38) | ALDH1A1GAACYP1A2KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |