Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246127 | 0.90 | NQO2 (0.48) | NQO2IDO1DRD2MTNR1AMTNR1B | |
| SCHEMBL2948649 | 0.87 | GAA (0.50) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL7771175 | 0.83 | NQO2 (0.46) | NQO2IDO1DRD2 | |
| SCHEMBL6675032 | 0.83 | NQO2 (0.49) | NQO2MAPTHTTIDO1ALDH1A1 | |
| SCHEMBL6676049 | 0.83 | IDO1 (0.55) | NQO2GAAMAPTTSHRHTT | |
| SCHEMBL20968300 | 0.83 | NQO2 (0.51) | NQO2HTTIDO1ALDH1A1 | |
| SCHEMBL28350815 | 0.82 | MAPT (0.49) | NQO2GAAMAPTHTTIDO1 | |
| SCHEMBL8419482 | 0.81 | MTNR1A (0.67) | NQO2HTTIDO1DRD2MTNR1A | |
| SCHEMBL7244826 | 0.81 | ALDH1A1 (0.54) | NQO2GAAIDO1DRD2ALDH1A1 | |
| SCHEMBL7449161 | 0.81 | CA12 (0.50) | GAAIDO1DRD2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| CN-1075808-C | Aniline derivatives having nitric oxide synthase inhibitory activity | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2001-12-05 | — | — | CN | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |