Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | AOC1 | P19801 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6680340 | 0.80 | EPHX2 (0.36) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| Hydrochloric Acid SCHEMBL6683830 | 0.79 | HTR2C (0.45) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| SCHEMBL6682696 | 0.78 | EPHX2 (0.36) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| SCHEMBL6683447 | 0.78 | HTR2C (0.38) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| SCHEMBL6684558 | 0.78 | MEN1 (0.37) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| Hydrochloric Acid SCHEMBL6685217 | 0.77 | HTR2C (0.37) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| Hydrochloric Acid SCHEMBL7054932 | 0.77 | HTR2C (0.43) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| Hydrochloric Acid SCHEMBL6682397 | 0.77 | HTR2C (0.37) | EPHX2SMN1; SMN2LMNARAB9AHSD11B1 | |
| SCHEMBL7813283 | 0.74 | HSD11B1 (0.44) | EPHX2LMNAHSD11B1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6681676 | 0.72 | GAA (0.37) | EPHX2ALDH1A1MAPTHTR2CP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828318-B2 | Amines such as 2-(2-(2-phenyl)adamantyl)ethylamine, used as neurotransmitter antagonists, for prophylaxis of neurodegenerative disorders and as analgesics | VERNALIS RESEARCH LIMITED (GB) | 2004-12-07 | — | — | US | disclosed |
| EP-1305306-B1 | 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RES LTD (GB) | 2004-11-24 | — | — | EP | disclosed |
| US-20030207881-A1 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission | VERNALIS RESEARCH LIMITED (GB) | 2003-11-06 | — | — | US | disclosed |
| EP-1305306-A2 | 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008219-A2 | 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207881-A1 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission | SLC1A2, SLC18A2, GRM2 | EPHX2 784/4885SMN1; SMN2 996/4885LMNA 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.