Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227746 | 0.87 | PTGDR2 (0.42) | PTGDR2CRHR1LMNAALDH1A1RHEB | |
| SCHEMBL509269 | 0.81 | MAPT (0.36) | PTGDR2CRHR1MPOLMNAATM | |
| SCHEMBL5226171 | 0.78 | FPR2 (0.41) | PTGDR2CRHR1LMNAMARS1TSHR | |
| SCHEMBL6626065 | 0.70 | PDE4B (0.35) | PTGDR2GPBAR1 | |
| SCHEMBL5224650 | 0.69 | PGR (0.39) | PTGDR2LMNAALDH1A1BRD4BRD2 | |
| SCHEMBL5225100 | 0.68 | MAPK14 (0.37) | PTGDR2LMNAATMALDH1A1TSHR | |
| SCHEMBL5228227 | 0.68 | PTGDR2 (0.40) | PTGDR2LMNARHEBHTTKMT2A | |
| SCHEMBL5229746 | 0.67 | P2RX7 (0.37) | PTGDR2CRHR1ATMMEN1KMT2A | |
| SCHEMBL509302 | 0.67 | PTGDR2 (0.38) | PTGDR2CRHR1ALDH1A1BRD4BRD2 | |
| SCHEMBL5224661 | 0.66 | P2RX7 (0.34) | PTGDR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377556-A1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | Pfizer Limited (GB) | 2004-01-07 | — | — | EP | claimed |
| WO-2002085860-A1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | PFIZER LIMITED (GB) | 2002-10-31 | — | — | WO | claimed |