Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676127 | 0.88 | CA2 (0.44) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL6680718 | 0.87 | CA2 (0.43) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL6675053 | 0.86 | CA1 (0.46) | CA2CA1NAMPTMAPT | |
| SCHEMBL2876047 | 0.81 | CA2 (0.51) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL6680633 | 0.80 | CA2 (0.49) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL8771747 | 0.79 | CA2 (0.39) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL6680795 | 0.78 | NQO2 (0.43) | CA2CA1NQO2MAPTGAA | |
| SCHEMBL1128630 | 0.77 | CA2 (0.49) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL3696922 | 0.77 | NQO2 (0.47) | CA2CA1NAMPTPTGER4NQO2 | |
| SCHEMBL6681889 | 0.76 | KMT2A (0.47) | CA2CA1NAMPTNQO2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |