SCHEMBL668190

SCHEMBL668190

FC(F)(F)[Cu]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL25252062 0.93
SCHEMBL10416601 0.72
SCHEMBL2992041 0.67
Iodide SCHEMBL11020380 0.62
Hydrochloric Acid SCHEMBL1452996 0.62
Bromide SCHEMBL9810690 0.62
SCHEMBL21244130 0.62
SCHEMBL14721708 0.61
SCHEMBL24604 0.61
SCHEMBL444758 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 259 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118852101-A Sulfonyloxy high-valence iodized salt and preparation method thereof 中国人民解放军军事科学院防化研究院 2024-10-29 CN claimed
CN-115626861-B Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-06-20 CN claimed
CN-115626861-A Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-01-20 CN claimed
CN-114933758-A Quantum dot thin film material with gas-sensitive performance and application thereof 江苏烨湫传感科技有限公司 2022-08-23 CN claimed
CN-110330492-A A kind of mycobacterium tuberculosis activity inhibitor prodrug synthesis method 安庆济达生物科技有限公司 2019-10-15 CN claimed
EP-2678302-B1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION FUNDACIÓ INST CATALÀ D INVESTIGACIÓ QUÍMICA (ES) 2016-08-17 EP claimed
EP-2678302-A1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION Fundació Institut Català d'Investigació Química (ES) 2014-01-01 EP claimed
WO-2012113726-A1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION FUNDACIÓ PRIVADA INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) (ES) 2012-08-30 WO claimed
EP-1017687-A4 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 MERCK & CO INC (US) 2001-10-31 EP claimed
EP-1017687-A1 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 Merck & Co., Inc. (US) 2000-07-12 EP claimed
US-5922906-A NOVEL AROMATIC NITRO GROUP DISPLACEMENT TO GENERATE A KEY INTERMEDIATE IN THE SYNTHESIS OF THE 2,4-BIS(TRIFLOUROMETHYL)PHENYLACETIC ACID SIDE CHAIN OF A CLASS III ANTIARRHYTHMIC AGENT MERCK & COMPANY, INC. (US) 1999-07-13 US claimed
WO-1999015513-A1 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 MERCK & CO., INC. (US) 1999-04-01 WO claimed
EP-0372982-B1 Pyrrole insecticides RHONE POULENC AGROCHIMIE (FR) 1997-07-02 EP claimed
CN-1028475-C Pyrrole insecticides RHONE POULENC AGROCHIMIE (FR) 1995-05-24 CN claimed
CN-1063104-A Trifluoromethyl 1-carbon (1-desulfuration) cephem LILLY CO ELI (US) 1992-07-29 CN claimed
EP-0494733-A1 Trifluoromethyl 1-carba(1-dethia)cephems ELI LILLY AND COMPANY (US) 1992-07-15 EP claimed
CN-1043500-A PYRROLE INSECTICIDES RHONE POULENC AGROCHIMIE (FR) 1990-07-04 CN claimed
EP-0372982-A2 Pyrrole insecticides RHONE-POULENC AGROCHIMIE (FR) 1990-06-13 EP claimed
US-4650887-A TRIFLUOROMETHYLCOPPER REAGENT UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1987-03-17 US claimed
JP-3081263-A None JP disclosed
JP-6056817-A None JP disclosed
CN-122103041-A Synthesis method of 4-trifluoroethyl-2-quinazolinone compound 2026-05-29 CN disclosed
US-20260078122-A1 INDAZOLE COMPOUNDS AS PKMYT1 KINASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-03-19 US disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
EP-4673436-A1 INDAZOLE COMPOUNDS AS PKMYT1 KINASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2026-01-07 EP disclosed
US-20250320196-A1 APOL1 INHIBITORS AND METHODS OF USES THEREOF MAZE THERAPEUTICS INC (US) 2025-10-16 US disclosed
EP-3954685-B1 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF US HEALTH (US) 2025-08-27 EP disclosed
EP-4605392-A1 METHODS FOR TREATING CANCER Antares Therapeutics, Inc. (US) 2025-08-27 EP disclosed
US-12365653-B2 Small molecule inhibitors of lactate dehydrogenase and methods of use thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) 2025-07-22 US disclosed
CN-116903499-B Anhydrous fluorosulfonyl difluoro copper acetate salt, preparation method and application thereof 上海应用技术大学 2025-05-30 CN disclosed
WO-2025076523-A1 RAS INHIBITORS AND METHODS OF USE THEREOF KESTREL THERAPEUTICS, INC. (US) 2025-04-10 WO disclosed
US-20240368087-A1 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2024-11-07 US disclosed
CN-118852101-A Sulfonyloxy high-valence iodized salt and preparation method thereof 中国人民解放军军事科学院防化研究院 2024-10-29 CN disclosed
WO-2024179948-A1 INDAZOLE COMPOUNDS AS PKMYT1 KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2024-09-06 WO disclosed
US-20240140957-A1 BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF BEONE MEDICINES I GMBH (CH) 2024-05-02 US disclosed
CN-117946153-A Synthesis method of 3, 3-trifluoro lactic acid 四川富华信新材料科技有限公司 2024-04-30 CN disclosed
WO-2024086809-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. (US) 2024-04-25 WO disclosed
US-20240092739-A1 COMPOUNDS AND METHODS OF USE VENTHERA, INC. 2024-03-21 US disclosed
CN-112119075-B Condensed ring compound 豪夫迈·罗氏有限公司 2024-03-12 CN disclosed
US-11918571-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2024-03-05 US disclosed
US-11897845-B2 Small molecule inhibitors of lactate dehydrogenase and methods of use thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-02-13 US disclosed
CN-117534620-A Preparation method of palladium-catalyzed hydrocarbon bond functionalized 2-trifluoromethyl benzimidazole compound 六盘水师范学院 2024-02-09 CN disclosed
CN-117529477-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2024-02-06 CN disclosed
EP-3660003-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-01-24 EP disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
CN-116903499-A Anhydrous fluorosulfonyl difluoro copper acetate salt, preparation method and application thereof 上海应用技术大学 2023-10-20 CN disclosed
US-11773099-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2023-10-03 US disclosed
WO-2023165525-A1 DIACYLGLYCEROL KINASE (DGK) ALPHA INHIBITORS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2023-09-07 WO disclosed
US-11713311-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-08-01 US disclosed
CN-116478131-A 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors 锐新医药公司 2023-07-25 CN disclosed
EP-4204412-A1 HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF InventisBio Co., Ltd. (CN) 2023-07-05 EP disclosed
CN-115626861-B Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-06-20 CN disclosed
CN-115626861-B Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-06-20 CN disclosed
US-20230145249-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-05-11 US disclosed
CN-112979721-B Preparation method of high-purity antineoplastic medicine troflucytidine 江苏集萃分子工程研究院有限公司 2023-05-09 CN disclosed
CN-109983001-B 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors 锐新医药公司 2023-04-04 CN disclosed
EP-4125892-A1 FACTOR XI ACTIVATION INHIBITORS Merck Sharp & Dohme LLC (US) 2023-02-08 EP disclosed
CN-115626861-A Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-01-20 CN disclosed
CN-115626861-A Method for synthesizing trifluoromethyl aromatic compound 山东东岳化工有限公司 2023-01-20 CN disclosed
US-20220388995-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-12-08 US disclosed
CN-108834412-B Pyrimidines and variants thereof, and uses thereof 传入制药公司 2022-11-25 CN disclosed
CN-115243687-A N- (heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions and uses thereof 默沙东有限责任公司 2022-10-25 CN disclosed
US-20220332713-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2022-10-20 US disclosed
CN-110668913-B Preparation method of trifluoroethyl compound 江苏三美化工有限公司 2022-09-20 CN disclosed
CN-114933758-A Quantum dot thin film material with gas-sensitive performance and application thereof 江苏烨湫传感科技有限公司 2022-08-23 CN disclosed
CN-112574148-B Preparation method of 4,4'- (4,4' -isopropylidenediphenoxy) bis (phthalic anhydride) 天津众泰材料科技有限公司 2022-08-16 CN disclosed
WO-2022161489-A1 PENTAHETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 上海艾力斯医药科技股份有限公司 2022-08-04 WO disclosed
US-20220220078-A1 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-07-14 US disclosed
US-20220218681-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2022-07-14 US disclosed
CN-114540024-A Perovskite quantum dot material with gas-sensitive property and application thereof 江苏烨湫传感科技有限公司 2022-05-27 CN disclosed
US-11278535-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2022-03-22 US disclosed
WO-2022042657-A1 COMPOUNDS AND METHODS OF USE Ferro Therapeutics, Inc. (US) 2022-03-03 WO disclosed
EP-3954685-A1 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF The United States Of America, As Represented By The Secretary, Department Of Health And Human Services (US) 2022-02-16 EP disclosed
US-11247971-B2 Small molecule inhibitors of lactate dehydrogenase and methods of use thereof THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2022-02-15 US disclosed
CN-108779119-B Pyrimidines and variants thereof, and uses thereof 传入制药公司 2022-02-08 CN disclosed
US-11230541-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-01-25 US disclosed
CN-113631552-A Pesticidally active azoleamide compounds 先正达农作物保护股份公司 2021-11-09 CN disclosed
US-11072585-B2 Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof PHARMAKEA, INC. (US) 2021-07-27 US disclosed
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2021-06-24 US disclosed
CN-112979721-A Preparation method of high-purity antitumor drug troflurocytidine 江苏集萃分子工程研究院有限公司 2021-06-18 CN disclosed
EP-3795568-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF Pharmakea, Inc. (US) 2021-03-24 EP disclosed
EP-3746436-A1 FUSED RING COMPOUNDS F. Hoffmann-La Roche AG (CH) 2020-12-09 EP disclosed
US-20200377506-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2020-12-03 US disclosed
EP-3265456-B1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA INC (US) 2020-11-18 EP disclosed
CN-109627209-B Preparation method of 2- (trifluoromethyl) pyridine-3-formaldehyde (I) 浙江工业大学上虞研究院有限公司 2020-09-01 CN disclosed
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2020-06-11 US disclosed
EP-3660003-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2020-06-03 EP disclosed
US-20200115341-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA, INC. 2020-04-16 US disclosed
CN-109336794-B Synthetic method of aryl vinyl trifluoro methyl sulfide compound 江南大学 2020-04-07 CN disclosed
US-10570094-B2 Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof PHARMAKEA, INC. (US) 2020-02-25 US disclosed
WO-2020035031-A1 FUSED RING COMPOUNDS GENENTECH, INC. (US) 2020-02-20 WO disclosed
CN-110668913-A Preparation method of trifluoroethyl compound 江苏三美化工有限公司 2020-01-10 CN disclosed
CN-110330492-A A kind of mycobacterium tuberculosis activity inhibitor prodrug synthesis method 安庆济达生物科技有限公司 2019-10-15 CN disclosed
CN-110330492-A A kind of mycobacterium tuberculosis activity inhibitor prodrug synthesis method 安庆济达生物科技有限公司 2019-10-15 CN disclosed
EP-3510404-A1 CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF Pharmakea, Inc. (US) 2019-07-17 EP disclosed
US-20190192697-A1 CHEMICAL PROBES OF LYSYL OXIDASK-LIKE 2 AND USES THEREOF PHARMAKEA, INC. 2019-06-27 US disclosed
US-20190119211-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA, INC. 2019-04-25 US disclosed
CN-109627209-A The preparation method of 2- (trifluoromethyl) pyridine -3- formaldehyde (I) 浙江工业大学上虞研究院有限公司 2019-04-16 CN disclosed
US-10150732-B2 Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof PHARMAKEA, INC. (US) 2018-12-11 US disclosed
CN-108473498-A Pyrazolo [1,5a] pyrimidine derivatives as IRAK4 conditioning agents 豪夫迈·罗氏有限公司 2018-08-31 CN disclosed
CN-105541698-B A kind of preparation method of the bromo- 2- trifluoromethyl pyridines of 5- 滨海康杰化学有限公司 2018-07-10 CN disclosed
WO-2018098500-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 WO disclosed
WO-2018048928-A1 CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF PHARMAKEA, INC. (US) 2018-03-15 WO disclosed
CN-107624112-A Small molecule inhibitors of lactate dehydrogenase and methods of use thereof 美国政府健康及人类服务部 2018-01-23 CN disclosed
EP-3265456-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF Pharmakea, Inc. (US) 2018-01-10 EP disclosed
US-20170369443-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA, INC. 2017-12-28 US disclosed
US-9758453-B2 One-component reagent for the fluoroalkylation reaction THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2017-09-12 US disclosed
CN-107001267-A Condensed heterocyclic compouds 马合伙人株式会社 2017-08-01 CN disclosed
US-9676795-B2 Process to obtain a trifluoromethylating composition FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ES) 2017-06-13 US disclosed
US-9475756-B2 Difluoromethylation of aryl and vinyl iodides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-10-25 US disclosed
WO-2016144703-A1 FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA, INC. (US) 2016-09-15 WO disclosed
EP-2678302-B1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION FUNDACIÓ INST CATALÀ D INVESTIGACIÓ QUÍMICA (ES) 2016-08-17 EP disclosed
US-20160185691-A1 One-Component Reagent for the Fluoroalkylation Reaction THE BOARD OF TRUSTEES OF THE UNIVERSITY OF LLLINOIS (US) 2016-06-30 US disclosed
CN-105541698-A Preparation method of 2-trifluoromethyl-5-bromopyridine BINHAI KANGJIE CHEMICAL CO LTD 2016-05-04 CN disclosed
US-9249071-B2 Modified polyaromatic hydrocarbons and polyheterocyclics for optoelectronics COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2016-02-02 US disclosed
US-9193648-B2 Fluoroalkylation methods and reagents BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2015-11-24 US disclosed
EP-1973404-B1 MALONONITRILE COMPOUNDS MERIAL INC (US) 2015-10-28 EP disclosed
US-20150274755-A1 COMPOUND DIVERSIFICATION USING LATE STAGE FUNCTIONALIZATION MERCK SHARP & DOHME CORP. 2015-10-01 US disclosed
WO-2015018855-A1 PENTAFLUOROETHYLATING COMPOSITIONS FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ES) 2015-02-12 WO disclosed
US-20150045580-A1 DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-02-12 US disclosed
EP-2835374-A1 Pentafluoroethylating compositions Fundació Institut Català d'Investigació Química (ES) 2015-02-11 EP disclosed
US-8916592-B2 Malononitrile compounds MERIAL LIMITED (US) 2014-12-23 US disclosed
US-8901170-B2 Malononitrile compounds BASF SE (DE) 2014-12-02 US disclosed
US-20140235866-A1 Process to Obtain a Trifluoromethylating Composition FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA (ES) 2014-08-21 US disclosed
US-20140221655-A1 MODIFIED POLYAROMATIC HYDROCARBONS AND POLYHETEROCYCLICS FOR OPTOELECTRONICS COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2014-08-07 US disclosed
EP-2678302-A1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION Fundació Institut Català d'Investigació Química (ES) 2014-01-01 EP disclosed
EP-1661897-B1 PYRROLOPYRIMIDINONE DERIVATIVE TEIJIN PHARMA LTD (JP) 2013-12-04 EP disclosed
WO-2013134296-A1 DIFLUOROMETHYLATION OF ARYL AND VINYL IODIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-09-12 WO disclosed
US-20130225815-A1 Fluoroalkylation Methods And Reagents THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2013-08-29 US disclosed
CN-101506150-B Malononitrile compounds BASF SE 2013-08-28 CN disclosed
EP-2606048-A1 FLUOROALKYLATION METHODS AND REAGENTS The Board of Trustees of the University of Illinois (US) 2013-06-26 EP disclosed
CN-1871240-B Pyrrolopyrimidine thion derivatives TEIJIN PHARMA LTD 2012-11-07 CN disclosed
WO-2012113726-A1 PROCESS TO OBTAIN A TRIFLUOROMETHYLATING COMPOSITION FUNDACIÓ PRIVADA INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) (ES) 2012-08-30 WO disclosed
CN-101384170-B Malononitrile compounds BASF SE 2012-07-18 CN disclosed
CN-101538243-B Malononitrile compounds and their use SUMITOMO CHEMICAL CO 2012-05-09 CN disclosed
CN-101544606-B Malononitrile compound and use thereof SUMITOMO CHEMICAL CO 2012-02-29 CN disclosed
WO-2012024564-A1 FLUOROALKYLATION METHODS AND REAGENTS THE BOARD OF TRUSTESS OF THE UNIVERSITY OF ILLINOIS (US) 2012-02-23 WO disclosed
CN-1910156-B Malononitrile compound as pesticide SUMITOMO CHEMICAL CO 2011-08-17 CN disclosed
EP-1710234-B1 MALONONITRILE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2011-07-13 EP disclosed
CN-1910147-B Malononitrile compounds and their use SUMITOMO CHEMICAL CO 2011-04-20 CN disclosed
US-7846956-B2 Malononitrile compound as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-12-07 US disclosed
US-20100215777-A1 Malononitrile Compounds BASF SE (DE) 2010-08-26 US disclosed
EP-2144890-A1 METHOD FOR PREPARING HALOGENATED AMINES Wyeth (US) 2010-01-20 EP disclosed
US-20090326012-A1 Malononitrile Compounds MERIAL, INC. 2009-12-31 US disclosed
CN-101544606-A Malononitrile compound and use thereof SUMITOMO CHEMICAL CO 2009-09-30 CN disclosed
CN-101538243-A Malononitrile compound and use thereof SUMITOMO CHEMICAL CO 2009-09-23 CN disclosed
CN-101506150-A Malononitrile compounds BASF SE (DE) 2009-08-12 CN disclosed
US-7557113-B2 Substituted pyrrolo[3,2-d]pyrimidine derivatives TEIJIN PHARMA LIMITED (JP) 2009-07-07 US disclosed
US-20090149425-A1 Malononitrile compound as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-11 US disclosed
US-7541374-B2 Malononitrile compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-06-02 US disclosed
US-20090136551-A1 Substituted Dicyanoalkanes For Combating Animal Pests BASF AKTIENGESELLSCHAFT (DE) 2009-05-28 US disclosed
EP-2044008-A1 MALONONITRILE COMPOUNDS BASF SE (DE) 2009-04-08 EP disclosed
CN-101384170-A Malononitrile compounds BASF SE (DE) 2009-03-11 CN disclosed
EP-1385817-B1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL CO (JP) 2008-12-03 EP disclosed
EP-1973404-A1 MALONONITRILE COMPOUNDS BASF SE (DE) 2008-10-01 EP disclosed
EP-1704143-B1 MALONONITRILE COMPOUND AS PESTICIDES SUMITOMO CHEMICAL CO (JP) 2008-09-03 EP disclosed
CN-100412064-C Malononitrile compounds and its use SUMITOMO CHEMICAL CO (JP) 2008-08-20 CN disclosed
WO-2008098103-A1 METHOD FOR PREPARING HALOGENATED AMINES WYETH (US) 2008-08-14 WO disclosed
US-20080188659-A1 Method for Preparing Halogenated Amines WYETH (US) 2008-08-07 US disclosed
US-7402691-B2 Malononitrile compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-07-22 US disclosed
EP-1912958-A1 SUBSTITUTED MALONONITRILE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2008-04-23 EP disclosed
EP-1555259-B1 Malononitrile compounds as pesticides SUMITOMO CHEMICAL CO (JP) 2008-01-02 EP disclosed
WO-2007147888-A1 MALONONITRILE COMPOUNDS BASF SE (DE) 2007-12-27 WO disclosed
CN-100343233-C Malononitrile compounds and their use SUMITOMO CHEMICAL CO (JP) 2007-10-17 CN disclosed
WO-2007071609-A1 MALONONITRILE COMPOUNDS BASF SE (DE) 2007-06-28 WO disclosed
US-20070117854-A1 Malononitrile compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-05-24 US disclosed
US-20070105826-A1 Novel fusidic acid derivatives LEO PHARMA A/S (DK) 2007-05-10 US disclosed
WO-2007017414-A1 SUBSTITUTED MALONONITRILE COMPOUNDS FOR COMBATING ANIMAL PESTS BASF SE (DE) 2007-02-15 WO disclosed
CN-1910156-A Malononitrile compound as pesticide SUMITOMO CHEMICAL CO (JP) 2007-02-07 CN disclosed
CN-1910147-A Malononitrile compounds and their use SUMITOMO CHEMICAL CO (JP) 2007-02-07 CN disclosed
CN-1871240-A Pyrrolopyrimidine thion derivatives TEIJIN PHARMA LTD (JP) 2006-11-29 CN disclosed
WO-2006122949-A1 MALONONITRILES AND THEIR USE AS PESTICIDES BASF AKTIENGESELLSCHAFT (DE) 2006-11-23 WO disclosed
EP-1521528-B1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL CO (JP) 2006-11-22 EP disclosed
EP-1151987-B1 OPTICALLY ACTIVE FLUORINATED BINAPHTHOL DERIVATIVE JAPAN SCIENCE & TECH AGENCY (JP) 2006-10-25 EP disclosed
EP-1710234-A1 MALONONITRILE COMPOUND AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2006-10-11 EP disclosed
EP-1704143-A1 MALONONITRILE COMPOUND AS PESTICIDES Sumitomo Chemical Company, Limited (JP) 2006-09-27 EP disclosed
US-20060160831-A1 Pyrrolopyrimidinone derivatives TEIJIN PHARMA LIMITED (JP) 2006-07-20 US disclosed
EP-1661896-A1 PYRROLOPYRIMIDINETHIONE DERIVATIVE Teijin Pharma Limited (JP) 2006-05-31 EP disclosed
EP-1661897-A1 PYRROLOPYRIMIDINONE DERIVATIVE Teijin Pharma Limited (JP) 2006-05-31 EP disclosed
EP-1658305-A1 NOVEL FUSIDIC ACID DERIVATIVES Leo Pharma A/S (DK) 2006-05-24 EP disclosed
US-7026340-B2 Malononitrile compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-04-11 US disclosed
US-7011838-B2 Malononitrile compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-03-14 US disclosed
EP-1176150-B1 PROCESS FOR THE PREPARATION OF TRIFLUOROTHYMIDINE DERIVATIVES MITSUI CHEMICALS INC (JP) 2005-10-19 EP disclosed
US-20050209323-A1 Malononitrile compounds and their use as pesticides OTAKA KEN 2005-09-22 US disclosed
CN-1668195-A Malononitrile compounds and their uses SUMITOMO CHEMICAL CO (JP) 2005-09-14 CN disclosed
US-20050176784-A1 Malononitrile compounds and their use as pesticides SUMITOMO CHECMICAL COMPANY, LIMITED (JP) 2005-08-11 US disclosed
CN-1648122-A Malononitrile compounds and its use SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
WO-2005068432-A1 MALONONITRILE COMPOUND AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-07-28 WO disclosed
EP-1555259-A1 Malononitrile compounds as pesticides Sumitomo Chemical Company, Limited (JP) 2005-07-20 EP disclosed
US-20050153992-A1 Pyrrolopyrimidine thion derivatives TEIJIN PHARMA LIMITED (JP) 2005-07-14 US disclosed
EP-1521528-A1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES Sumitomo Chemical Company, Limited (JP) 2005-04-13 EP disclosed
CN-1191265-C Process for preparing trifluorothymidine derivatives MITSUI CHEMICALS INC (JP) 2005-03-02 CN disclosed
WO-2005007669-A1 NOVEL FUSIDIC ACID DERIVATIVES LEO PHARMA A/S (DK) 2005-01-27 WO disclosed
US-20040143007-A1 Malononitrile compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-22 US disclosed
US-20040142821-A1 Pesticide composition comprising malononitrile compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-22 US disclosed
US-20040138065-A1 Malononitrile compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-15 US disclosed
EP-1392647-A1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-03-03 EP disclosed
EP-1385377-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-02-04 EP disclosed
EP-1385817-A2 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2004-02-04 EP disclosed
WO-2004006677-A1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-01-22 WO disclosed
CN-1131219-C Process for preparation of phenylimidazolidine derivs. HOECHST MARION ROUSSEL INC (FR) 2003-12-17 CN disclosed
WO-2002089579-A1 PESTICIDE COMPOSITION COMPRISING MALONONITRILE COMPOUNDS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed
WO-2002090321-A1 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed
WO-2002090320-A2 MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-11-14 WO disclosed
US-6476250-B1 Optically active fluorinated binaphthol derivative JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) 2002-11-05 US disclosed
EP-0990651-B1 Process for producing 5-trifluoromethyluracil derivatives MITSUI CHEMICALS INC (JP) 2002-10-09 EP disclosed
CN-1366530-A Process for preparing trifluorothymidine derivatives MITSUI CHEMICALS INC (JP) 2002-08-28 CN disclosed
US-6423852-B1 REACTING 5-TRIFLUOROMETHYL-2,4-BIS(TRIMETHYLSILYLOXY)PYRIMIDINE WITH2-DEOXY-A-ERYTHROPENTAFLURANOSYL CHLORIDE MITSUI CHEMICALS, INC. (JP) 2002-07-23 US disclosed
EP-1176150-A1 PROCESS FOR THE PREPARATION OF TRIFLUOROTHYMIDINE DERIVATIVES Mitsui Chemicals, Inc. (JP) 2002-01-30 EP disclosed
EP-1151987-A1 OPTICALLY ACTIVE FLUORINATED BINAPHTHOL DERIVATIVE Japan Science and Technology Corporation (JP) 2001-11-07 EP disclosed
EP-1017687-A4 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 MERCK & CO INC (US) 2001-10-31 EP disclosed
US-6140515-A Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of COX-2 MERCK & CO., INC. (US) 2000-10-31 US disclosed
EP-1017687-A1 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 Merck & Co., Inc. (US) 2000-07-12 EP disclosed
EP-0635517-B1 Process for Producing 1-(2'-deoxy-beta-D-erythropentofuranosyl)-5-trifluoromethyluracil Derivatives MITSUI CHEMICALS INC (JP) 2000-05-17 EP disclosed
EP-0990651-A1 Process for producing 5-trifluoromethyluracil derivatives Mitsui Chemicals, Inc. (JP) 2000-04-05 EP disclosed
US-5922906-A NOVEL AROMATIC NITRO GROUP DISPLACEMENT TO GENERATE A KEY INTERMEDIATE IN THE SYNTHESIS OF THE 2,4-BIS(TRIFLOUROMETHYL)PHENYLACETIC ACID SIDE CHAIN OF A CLASS III ANTIARRHYTHMIC AGENT MERCK & COMPANY, INC. (US) 1999-07-13 US disclosed
WO-1999015513-A1 PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2 MERCK & CO., INC. (US) 1999-04-01 WO disclosed
CN-1207732-A Process for preparation of phenylimidazolidine derivs. HOECHST MARION ROUSSEL INC (FR) 1999-02-10 CN disclosed
EP-0460940-B1 Pesticidal 1-arylpyrroles RHONE POULENC AGROCHIMIE (FR) 1999-01-27 EP disclosed
US-5852023-A Cyclohexylamino and cycloalkoxy nitrogen heterocycles, processes for their preparation, and their use as pesticides and fungicides HOECHST SCHERING AGREVO GMBH (DE) 1998-12-22 US disclosed
CN-1039079-C Pesticidal 1-arylpyrroles RHONE POULENC AGROCHIMIE (FR) 1998-07-15 CN disclosed
CN-1179773-A Cyclohexylamino and cyclohexylalkoxy nitrogen heterocycles, methods of preparing them and their use as pest-control agents and fungicides HOECHST SCHERING AGREVO GMBH (DE) 1998-04-22 CN disclosed
EP-0493925-B1 Pyrazole derivatives having herbicidal activity, their preparation and their use SANKYO CO (JP) 1997-11-05 EP disclosed
EP-0372982-B1 Pyrrole insecticides RHONE POULENC AGROCHIMIE (FR) 1997-07-02 EP disclosed
US-5532349-A ANTITUMOR, VIRICIDES MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-02 US disclosed
US-5506260-A INSECTICIDES, ACARICIDES, NEMATOCIDES RHONE-POULENC AG COMPANY (US) 1996-04-09 US disclosed
CN-1030912-C Pyrazole derivatives having herbicidal activity, preparation and use thereof SANKYO CO (JP) 1996-02-07 CN disclosed
US-5424279-A Useful for rice crops SANKYO COMPANY, LIMITED (JP) 1995-06-13 US disclosed
CN-1028475-C Pyrrole insecticides RHONE POULENC AGROCHIMIE (FR) 1995-05-24 CN disclosed
EP-0635517-A1 Process for Producing 1-(2'-deoxy-beta-D-erythropentofuranosyl)-5-trifluoromethyluracil Derivatives MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-01-25 EP disclosed
EP-0253310-B1 Angiotensin II receptor blocking imidazoles DU PONT (US) 1994-10-26 EP disclosed
JP-H0656817-A 5-TRIFLUOROMETHYL-1,3-DIOXIN-4-ONE DERIVATIVE CHUGAI PHARMACEUT CO LTD 1994-03-01 JP disclosed
US-5187185-A Pesticidal 1-arylpyrroles RHONE-POULENC AG COMPANY (US) 1993-02-16 US disclosed
CN-1063282-A Pyrazole derivatives and preparation and application with weeding activity SANKYO CO (JP) 1992-08-05 CN disclosed
CN-1063104-A Trifluoromethyl 1-carbon (1-desulfuration) cephem LILLY CO ELI (US) 1992-07-29 CN disclosed
EP-0494733-A1 Trifluoromethyl 1-carba(1-dethia)cephems ELI LILLY AND COMPANY (US) 1992-07-15 EP disclosed
EP-0493925-A1 Pyrazole derivatives having herbicidal activity, their preparation and their use Sankyo Company Limited (JP) 1992-07-08 EP disclosed
US-5099015-A Antibiotics formed by bromination of trifluoromethanesulfonyl containing cephalosporins ELI LILLY AND COMPANY (US) 1992-03-24 US disclosed
CN-1057050-A 1-arylpyrrole insecticidal medicine RHONE POULENC AGROCHIMIE (FR) 1991-12-18 CN disclosed
EP-0460940-A1 Pesticidal 1-arylpyrroles RHONE-POULENC AGROCHIMIE (FR) 1991-12-11 EP disclosed
JP-H0381263-A 2-TRIFLUOROMETHYLNICOTINIC ACID DERIVATIVE ISHIHARA SANGYO KAISHA LTD 1991-04-05 JP disclosed
US-5001119-A 16-substituted androstanes and 16-substituted androstenes NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 1991-03-19 US disclosed
US-4990699-A Perfluoroalkylation process ETHYL CORPORATION (US) 1991-02-05 US disclosed
CN-1043500-A PYRROLE INSECTICIDES RHONE POULENC AGROCHIMIE (FR) 1990-07-04 CN disclosed
EP-0372982-A2 Pyrrole insecticides RHONE-POULENC AGROCHIMIE (FR) 1990-06-13 EP disclosed
US-4895991-A FROM AROMATIC HALIDE, DIFLUORODIHALOMETHANE, COPPER, CHAIN EXTENSION SUPPRESSING HALIDE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1990-01-23 US disclosed
US-4895991-A FROM AROMATIC HALIDE, DIFLUORODIHALOMETHANE, COPPER, CHAIN EXTENSION SUPPRESSING HALIDE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1990-01-23 US disclosed
US-4895991-A FROM AROMATIC HALIDE, DIFLUORODIHALOMETHANE, COPPER, CHAIN EXTENSION SUPPRESSING HALIDE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1990-01-23 US disclosed
US-4812454-A Nitromethylene derivatives and their use as insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-03-14 US disclosed
US-4772620-A MITICIDES, PARASITICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1988-09-20 US disclosed
US-4749802-A REACTING COPPER WITH A DIFLUORODIHALOMETHANE UNIVERSITY OF IOWA RESEARCH FOUNDATION, INC. (US) 1988-06-07 US disclosed
US-4749802-A REACTING COPPER WITH A DIFLUORODIHALOMETHANE UNIVERSITY OF IOWA RESEARCH FOUNDATION, INC. (US) 1988-06-07 US disclosed
US-4749802-A REACTING COPPER WITH A DIFLUORODIHALOMETHANE UNIVERSITY OF IOWA RESEARCH FOUNDATION, INC. (US) 1988-06-07 US disclosed
CN-86106238-A New nitromethylene derivatives 1987-04-08 CN disclosed
US-4650887-A TRIFLUOROMETHYLCOPPER REAGENT UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1987-03-17 US disclosed
US-4582921-A REACTING DIFLUORIDIHALOMETHANE WITH CADIUM OR ZINC IN APROTIC SOLVENT UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1986-04-15 US disclosed
EP-0000200-B1 NEW N-AMIDINO-3,5-DIAMINO-6-SUBSTITUTED-2-PYRAZINECARBOXAMIDES AND PROCESS FOR PREPARING SAME MERCK & CO. INC. (US) 1982-03-24 EP disclosed
US-4207266-A CARBON TETRALIDE, HYDROGEN FLUORIDE, LEWIS ACID AD AROMATIC HYDROCARBON ROHM AND HAAS COMPANY (US) 1980-06-10 US disclosed
US-4207266-A CARBON TETRALIDE, HYDROGEN FLUORIDE, LEWIS ACID AD AROMATIC HYDROCARBON ROHM AND HAAS COMPANY (US) 1980-06-10 US disclosed