Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GNRHR | P30968 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3309669 | 0.87 | AKR1C3 (0.39) | ALDH1A1LMNAHPGDMAPTMMP1 | |
| SCHEMBL8168061 | 0.87 | ALOX5 (0.41) | ALDH1A1LMNAMAPTMMP1MMP2 | |
| SCHEMBL8164140 | 0.86 | KMT2A (0.44) | ALDH1A1LMNAMAPTTDP1KMT2A | |
| SCHEMBL16306995 | 0.86 | ITGA4 (0.41) | ALDH1A1LMNAMAPTMMP1MMP2 | |
| SCHEMBL8163578 | 0.86 | ITGA4 (0.41) | ALDH1A1LMNAMAPTMMP1MMP2 | |
| SCHEMBL31468989 | 0.86 | ITGA4 (0.41) | ALDH1A1LMNAMAPTMMP1MMP2 | |
| SCHEMBL3309773 | 0.86 | ITGA4 (0.41) | ALDH1A1LMNAMAPTMMP1MMP2 | |
| SCHEMBL8164897 | 0.86 | ALDH1A1 (0.44) | ALDH1A1LMNAGAAHTT | |
| SCHEMBL3304099 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTGAAKMT2A | |
| SCHEMBL8168021 | 0.85 | ITGA4 (0.41) | ALDH1A1LMNAMAPTGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |