Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.63 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422768 | 0.96 | KDM4E (0.67) | LMNAKDM4EKMT2AAPEX1AGTR1 | |
| SCHEMBL540895 | 0.91 | TP53 (0.65) | LMNAKDM4EAPEX1AGTR1AGTR2 | |
| SCHEMBL22639681 | 0.85 | KMT2A (0.74) | LMNAKDM4EKMT2AAPEX1SMN1; SMN2 | |
| SCHEMBL2361056 | 0.85 | TP53 (0.69) | LMNAKMT2ATP53SMN1; SMN2HTT | |
| SCHEMBL9533881 | 0.85 | CHRM1 (0.55) | LMNAKDM4EKMT2AAGTR1AGTR2 | |
| SCHEMBL28481747 | 0.84 | LMNA (0.81) | LMNAKMT2AAGTR1AGTR2TP53 | |
| SCHEMBL29411883 | 0.84 | LMNA (0.81) | LMNAKMT2AAGTR1AGTR2TP53 | |
| SCHEMBL28860662 | 0.84 | LMNA (0.67) | LMNAAGTR1AGTR2TP53SMN1; SMN2 | |
| SCHEMBL28716632 | 0.84 | LMNA (0.67) | LMNAAGTR1AGTR2TP53SMN1; SMN2 | |
| SCHEMBL28879019 | 0.84 | LMNA (0.67) | LMNAAGTR1AGTR2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | LMNA 3119/4885KDM4E 1893/4885KMT2A 1777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.