SCHEMBL6682738

SCHEMBL6682738

Cc1cc2c([C@@H]3C[C@H]3CN)cccc2o1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 20/20 0.54
HTR2B P41595 18/20 0.54
HTR2A P28223 13/20 0.54
SLC6A4 P31645 3/20 0.50
SLC6A3 Q01959 2/20 0.50
SLC6A2 P23975 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6682734 1.00 HTR2C (0.54) HTR2CHTR2BHTR2ASLC6A4SLC6A3
SCHEMBL8487261 0.81 SLC6A4 (0.36) HTR2CHTR2BHTR2ASLC6A4SLC6A3
Methylamine SCHEMBL27481947 0.81 MTNR1A (0.34) HTR2CHTR2BHTR2ASLC6A4SLC6A3
SCHEMBL27463661 0.80 MTNR1A (0.36) HTR2CHTR2BHTR2ASLC6A4SLC6A3
SCHEMBL8487259 0.80 MTNR1A (0.36) HTR2CHTR2BHTR2ASLC6A4SLC6A3
SCHEMBL6677201 0.79 MTNR1B (0.65) SLC6A4
SCHEMBL6677207 0.79 MTNR1B (0.65) SLC6A4
Methyl Alcohol SCHEMBL27547344 0.78 MTNR1A (0.37) SLC6A4SLC6A3SLC6A2
SCHEMBL6677834 0.77 MTNR1B (0.66) SLC6A4
SCHEMBL6677838 0.77 MTNR1B (0.66) SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
US-5856529-A ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-05 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed