Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786678 | 0.83 | GABRA1 (0.36) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL10781100 | 0.80 | GABRA1 (0.42) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL300454 | 0.79 | GABRA1 (0.45) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL7646706 | 0.77 | GABRA1 (0.40) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL29900352 | 0.70 | GABRA1 (0.61) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL2362466 | 0.70 | GABRA1 (0.61) | GABRA1GABRB2GAAKDM4ELMNA | |
| SCHEMBL29557747 | 0.70 | ALDH1A1 (0.42) | GAACYP3A4HPGDALOX15HTR2A | |
| SCHEMBL87732 | 0.70 | ALDH1A1 (0.42) | GAACYP3A4HPGDALOX15HTR2A | |
| Hydrochloric Acid SCHEMBL7927089 | 0.68 | ALDH1A1 (0.41) | CYP3A4HPGDALOX15HTR2AALDH1A1 | |
| SCHEMBL28875963 | 0.68 | HTR2B (0.38) | KDM4ELMNAHPGDHTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018076-B1 | 9-AMINOALKYLFLUORENES, PROCESS THEREFOR AND ANTIARRHYTHMIC FORMULATIONS THEREOF | ELI LILLY AND COMPANY (US) | 1983-09-21 | — | — | EP | claimed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | claimed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | claimed |
| EP-0904262-B1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-0187509-A3 | 9-AMINOALKYLFLUORENES | ELI LILLY AND COMPANY (US) | 1987-11-11 | — | — | EP | disclosed |
| US-4658061-A | ANTIARRHYTHMIC AGENTS | ELI LILLY AND COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4658061-A | ANTIARRHYTHMIC AGENTS | ELI LILLY AND COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0187509-A2 | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |
| EP-0187509-A2 | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4552982-A | Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes | ELI LILLY AND COMPANY (US) | 1985-11-12 | — | — | US | disclosed |
| US-4508735-A | ALSO ANESTHETIC | ELI LILLY AND COMPANY (US) | 1985-04-02 | — | — | US | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| US-4382093-A | 9-Aminoalkylfluorenes | ELI LILLY AND COMPANY (US) | 1983-05-03 | — | — | US | disclosed |
| EP-0038676-A1 | Process for preparing fluorene derivatives | ELI LILLY AND COMPANY (US) | 1981-10-28 | — | — | EP | disclosed |
| US-4282170-A | CHEMICAL INTERMEDIATES 9-AMINOALKYL-9-CARBAMOYL-FLUORENES | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4277495-A | FLUORENE 9-AMINOALKYL-9-CARBOXYLIC ACIDS OR ESTERS | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| EP-0018076-A1 | 9-Aminoalkylfluorenes, process therefor and antiarrhythmic formulations thereof | ELI LILLY AND COMPANY (US) | 1980-10-29 | — | — | EP | disclosed |
| US-4197313-A | USE OF 9-AMINOALKYL-9-(HYDROXY, CYANO OR CARBAMOYL)-FLUORENES | ELI LILLY AND COMPANY (US) | 1980-04-08 | — | — | US | disclosed |