Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049534 | 0.88 | TGFBR1 (0.60) | TGFBR1MAPK14THRBGAKRIPK2 | |
| SCHEMBL2044086 | 0.86 | TGFBR1 (0.49) | TGFBR1MAPK14THRBGAKRIPK2 | |
| SCHEMBL376179 | 0.84 | TGFBR1 (0.67) | TGFBR1MAPK14KDM4EMAPK1THRB | |
| SCHEMBL2045360 | 0.83 | TGFBR1 (0.47) | TGFBR1MAPK14THRBGAKRIPK2 | |
| Fluoromethane SCHEMBL27755992 | 0.82 | TGFBR1 (0.64) | TGFBR1MAPK14KDM4EMAPK1THRB | |
| SCHEMBL5875566 | 0.82 | TGFBR1 (0.45) | TGFBR1MAPK14KDM4EMAPK1NPSR1 | |
| SCHEMBL2052409 | 0.81 | TGFBR1 (0.51) | TGFBR1MAPK14THRB | |
| SCHEMBL2049330 | 0.81 | TGFBR1 (0.59) | TGFBR1MAPK14MAPK1NPSR1THRB | |
| SCHEMBL3242736 | 0.80 | TGFBR1 (0.48) | TGFBR1MAPK14 | |
| SCHEMBL5496438 | 0.79 | TGFBR1 (0.56) | TGFBR1MAPK14THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026302-A1 | METHODS OF INHIBITING TGF BETA WITH SUBSTITUTED PYRAZOLES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | claimed |
| WO-2004026302-A1 | METHODS OF INHIBITING TGF BETA WITH SUBSTITUTED PYRAZOLES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |