Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175852 | 0.92 | AGTR2 (0.53) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL9175859 | 0.92 | AGTR2 (0.53) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL6285084 | 0.90 | AGTR2 (0.52) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL6343357 | 0.90 | AGTR2 (0.52) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL16256994 | 0.89 | AGTR2 (0.51) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL21359881 | 0.89 | AGTR2 (0.51) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL3431539 | 0.89 | AGTR2 (0.51) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL14763059 | 0.88 | AGTR2 (0.50) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL9763260 | 0.88 | AGTR2 (0.50) | AGTR2SMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL21874593 | 0.87 | SMN1; SMN2 (0.58) | AGTR2SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004071454-A2 | SUBSTITUTED AZETIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | GUILFORD PHARMACEUTICALS INC. (US) | 2004-08-26 | — | — | WO | disclosed |