Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.39 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681124 | 0.82 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL6405338 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1MEN1POLBKMT2A | |
| SCHEMBL6412275 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1MEN1POLBKMT2A | |
| SCHEMBL6683202 | 0.77 | PTGS1 (0.41) | PTGS2PTGS1 | |
| SCHEMBL6685269 | 0.77 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL6680241 | 0.77 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL6683777 | 0.72 | PTGS2 (0.41) | PTGS2PTGS1P2RY6MEN1KMT2A | |
| SCHEMBL6684596 | 0.69 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL6682272 | 0.65 | PTGS1 (0.46) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL6680877 | 0.64 | PTGS2 (0.45) | PTGS2PTGS1P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274700-B1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORP (US) | 2004-11-17 | — | — | EP | claimed |