Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.44 |
| ▸ | MB | P02144 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313252 | 0.85 | CYP11B1 (0.56) | CYP11B1CYP11B2PDE3BPDE3AMB | |
| SCHEMBL24982282 | 0.81 | CHRNB2 (0.47) | CYP11B1CYP11B2PDE3BPDE3ACHRNB2 | |
| SCHEMBL29526300 | 0.74 | PDE3B (0.54) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL477609 | 0.74 | PDE3B (0.54) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL45104 | 0.74 | HTR5A (0.53) | CYP11B1CYP11B2PDE3BPDE3AMAPK1 | |
| SCHEMBL30494391 | 0.73 | CYP11B1 (0.49) | CYP11B1CYP11B2PDE3BPDE3AMAPK1 | |
| SCHEMBL26463448 | 0.73 | CYP11B1 (0.49) | CYP11B1CYP11B2PDE3BPDE3AMAPK1 | |
| SCHEMBL2233749 | 0.73 | NPC1 (0.55) | CYP11B1CYP11B2PDE3BPDE3ACHRNB2 | |
| Hydrochloric Acid SCHEMBL2362200 | 0.73 | PDE3B (0.53) | CYP11B1CYP11B2PDE3BPDE3ACYP1A2 | |
| SCHEMBL28939689 | 0.73 | PDE3B (0.38) | CYP11B1CYP11B2PDE3BPDE3ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978758-A1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014154762-A1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-02 | — | — | WO | disclosed |
| EP-1392686-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096907-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-05 | — | — | WO | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |