Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574240 | 0.98 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| Hydrochloric Acid SCHEMBL27198881 | 0.97 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| Oxalic Acid SCHEMBL4471151 | 0.89 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL21638189 | 0.88 | SLC6A4 (0.74) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL3203606 | 0.88 | SLC6A4 (0.74) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL17943011 | 0.82 | CARM1 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2CARM1 | |
| SCHEMBL7159318 | 0.81 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL19921484 | 0.81 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL18380998 | 0.81 | SLC6A4 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A | |
| SCHEMBL4471193 | 0.81 | SLC6A4 (0.58) | SLC6A2SLC6A4SLC6A3KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-11-25 | — | — | US | disclosed |
| US-6750228-B1 | UNCONTROLLED BREAKDOWN OF CONNECTIVE TISSUE BY METALLOPROTEASES IS A FEATURE OF MANY PATHOLOGICAL CONDITIONS | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP9, MMP13, MMP2 | SLC6A2 3721/4885SLC6A4 3160/4885SLC6A3 3293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.