Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711502 | 0.79 | HDAC1 (0.42) | APPAKR1C3AKR1C2KCNN4CYP3A4 | |
| SCHEMBL23070510 | 0.78 | MMP8 (0.37) | CYP3A4CYP1A2MAPK1HTT | |
| SCHEMBL18596249 | 0.77 | ALDH1A1 (0.41) | GAACYP1A2CYP2D6MEN1NPC1 | |
| SCHEMBL3503786 | 0.76 | APP (0.40) | APPAKR1C3AKR1C2KCNN4CYP3A4 | |
| SCHEMBL10704177 | 0.75 | APP (0.60) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL25168297 | 0.75 | CNR2 (0.48) | APPAKR1C3AKR1C2KCNN4CYP3A4 | |
| SCHEMBL29990602 | 0.75 | CNR2 (0.48) | APPAKR1C3AKR1C2KCNN4CYP3A4 | |
| SCHEMBL3714543 | 0.73 | ATM (0.50) | APPAKR1C3AKR1C2CYP3A4MEN1 | |
| SCHEMBL3714548 | 0.73 | ATM (0.50) | APPAKR1C3AKR1C2CYP3A4MEN1 | |
| SCHEMBL27609150 | 0.72 | NPC1 (0.48) | KCNN4HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073705-A1 | 1-PHENYL-2- MONOALKYL CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |