Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13447135 | 0.85 | CA12 (0.47) | MAPTLMNAKDM4EHSD17B10CASP1 | |
| SCHEMBL13447134 | 0.84 | ALOX5 (0.46) | MAPTLMNAKDM4EHSD17B10CA12 | |
| SCHEMBL5260351 | 0.83 | KDM5A (0.49) | MAPTLMNATP53CHEK1KDM4E | |
| SCHEMBL6488838 | 0.82 | KDM4E (0.59) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL13447133 | 0.81 | KDM4E (0.56) | MAPTTP53CHEK1KDM4EHSD17B10 | |
| SCHEMBL24500307 | 0.79 | KDM5A (0.59) | LMNAKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL29694785 | 0.79 | KDM5A (0.59) | LMNAKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL14195215 | 0.78 | CSF1R (0.50) | MAPTLMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7215720 | 0.77 | ALOX5 (0.56) | MAPTLMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL31017629 | 0.76 | HPGD (0.42) | MAPTLMNATP53MDM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | claimed |
| WO-2004060893-A1 | PYRROLOPYRIDINE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2004-07-22 | — | — | WO | claimed |
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | claimed |
| US-9580409-B2 | Modulators of opioid receptors and methods of use thereof | SUNOVION PHARMACEUTICALS, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20140288050-A1 | MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS, INC. | 2014-09-25 | — | — | US | disclosed |
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| WO-2004060893-A1 | PYRROLOPYRIDINE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | KCNJ2, KCNN1, KCNN2 | MAPT 1529/4885LMNA 2531/4885TP53 3740/4885 |
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | KCNJ2, KCNN1, KCNN2 | MAPT 1529/4885LMNA 2531/4885TP53 3740/4885 |
| US-20140288050-A1 | MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF | OPRM1, OPRK1, OPRL1 | MAPT 727/4885LMNA 3084/4885TP53 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.